Results 141 to 150 of about 1,197,354 (304)
DESIGN HISTORY AND SPECIFICATIONS FOR THE MARINER '69 HIGH-RESOLUTION TELESCOPE
, 1970 QC 351 A7 no. 51This report presents the author's basic findings on various optical systems that he studied and /or designed at the Jet Propulsion Laboratory, Pasadena, California, for the high -resolution telescope of NASA's Mariner '69 and '71 ...
Wilkerson, Gary W.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A TWO CHANNEL PHOTOGRAPHIC PLATE GUIDING CONTROL SYSTEM
, 1967 QC 351 A7 no. 20The control system described in this thesis was designed to automatically guide the position of photographic plates during long exposures of astronomical objects.
Reed, Michael A.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Harnessing the stem cell potential in the human hippocampus to limit cognitive aging. [PDF]
PLoS BiolMhatre S, Moore DL.
europepmc +1 more source
MULTIPLE SOURCE TESTING OF CAMERA SYSTEMS
, 1970 QC 351 A7 no. 54It is possible to use a target of two coherent point sources, with a separation much greater than the resolution limit of a diffraction -limited lens, to determine the best focus of a photographic system.
Rodriguez-Torres, Cristobal
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Geospatial dataset of oil wells and socio-environmental vulnerability indicators in coastal urban territories. [PDF]
Data BriefFreire D +4 more
europepmc +1 more source
OPTIMIZATION AND EVALUATION OF MANUFACTURING TOLERANCES OF A THREE-MIRROR ASPHERIC CAMERA
, 1971 QC 351 A7 no. 61In an attempt to design a three -mirror aspheric camera, a procedure was developed to arrive at a design with a minimum obscuration ratio.
Van Workum, John A.
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source