Results 141 to 150 of about 2,394,303 (304)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Openings in Very Formal Technical Texts

Discourse and Writing/Rédactologie, 1993
Michael P. Jordan
doaj   +1 more source

A simulation-based role-reversal training program improves knowledge, skills, and job satisfaction of endovascular scrub nurses. [PDF]

Surg Pract Sci
Lawaetz J, Siercke M, Skov R, Konge L, Van Herzeele I, Eiberg JP.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Text and Subtext in Designing Hands-on Course Notes

Discourse and Writing/Rédactologie, 1991
Chelva Kanaganayakam
doaj   +1 more source

Editorial: Unlocking the potential of health data: interoperability, security, and emerging challenges in AI, LLM, precision medicine, and their impact on healthcare and research. [PDF]

Front Digit Health
Rinaldi E, Kush R, Dalmiani S.
europepmc   +1 more source

VOICE PROBLEMS IN TRANSLATIONS OF ROMANIAN AND ENGLISH ECONOMIC TEXTS [PDF]

The difficulties brought about by the passive constructions have been an issue to debate for many linguists and scientist. Translations become ever more important in an increasingly global marketplace, and they are sometimes taken too lightly, when in ...
Sim Monica Ariana
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Teacher of Technical Writing in Canada: A Profile

Discourse and Writing/Rédactologie, 1985
Ron S. Blicq
doaj   +1 more source

Infrared imaging and intravascular laser irradiation of blood therapy for glycemic control in type 2 diabetes mellitus: a technical note. [PDF]

Front Med Technol
Candido PAC, Brioschi GC, Brioschi ML, Altruda KM.   +3 more
europepmc   +1 more source