Results 151 to 160 of about 89,555 (262)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Human resource challenges in leprosy control: A cross-sectional study in southwest border area of China. [PDF]

PLoS Negl Trop Dis
Song R, Shen Y, Guo F, Zhen Q, Kou S, Zha S, Yu X, Li Z, Song S, Hao J, Zhang Y, Wang Y, Ma T, Shui T, Yan X, Zhao W.   +15 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Agency-Level Turnover Rates of Emergency Medical Service Clinicians and Their Characteristics. [PDF]

J Am Coll Emerg Physicians Open
Kurth JD, Powell JR, Gage CB, Kamholz JC, van den Bergh S, Cash RE, Panchal AR.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Unlocking the potential of pharmacy technicians: Addressing barriers to full scope utilization in Canadian health care. [PDF]

Can Pharm J (Ott)
Galani TJ, Galani VJ.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

<i>Clostridioides difficile</i> clinical diagnostic test methods and results are associated with recovery of <i>C. difficile</i> by stool culture. [PDF]

Microbiol Spectr
Skinner AM, Guh AY, Petrella LA, Sambol S, Cheknis A, Johnson S, Czaja CA, Johnston H, Basiliere E, Dhonau RA, Korhonen L, Paulick AL, Samore MH, Adamczyk M, Gargis AS, Gerding DN.   +15 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The Use of Expressive Writing in Healthcare Professionals: A Systematic Review of Quantitative Studies. [PDF]

Healthcare (Basel)
Guasconi M, Dibennardo F, Cosentino C, Artioli G, Andriollo A, Pressi S, Rocchi M, Santona Galli S, Valente G, Bonacaro A.   +9 more
europepmc   +1 more source