Results 91 to 100 of about 4,459,271 (298)
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
The Musical Quarterly, 1916 IT is a source of wonder to many that while the average person has difficulty in attaining to even a fair degree of skill, certain individuals acquire quite a prodigious technical dexterity in their respective lines of work. It seems as if there must be some factor entering into the conditions more than the mere amount of labor and effort put forth by ...
openaire +2 more sources
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Grand Challenge at the Frontiers of Synaptic Neuroscience
Frontiers in Synaptic Neuroscience, 2021 P. Jesper Sjöström
doaj +1 more source
Nouvelles techniques d’examen des Helminthes : fixation ; coloration ; montage [PDF]
, 1953 J. Bailenger, E. Neuzil
openalex +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Islamic Spiritual Counseling Techniques [PDF]
Spiritual Psychology and Counseling, 2019 In this study, some Islamic counseling techniques that can be used in psychology have been integrated into the spiritual counseling process. It is thought that introducing and starting to use spiritual counseling techniques based on Islam, would be ...
Muhammet Şerif KESKİNOĞLU
doaj