Results 61 to 70 of about 43,142 (263)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A rapid design exploration framework under additive manufacturing process uncertainty

, 2018
Current computer-aided design (CAD) systems are not computationally efficient for exploring the growing design space of products manufactured with additive manufacturing (AM). A rapid method with sufficient fidelity is desired. Meanwhile, uncertainties
Xiong, Yi, Duong, Pham Luu Trung, Raghavan, Nagarajan, Rosen, David W   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A maturity assessment model for metal additive manufacturing: additive manufacturing readiness levels

This is an author's accepted manuscript of an article published by Taylor & Francis on 25/10/2025, available online: https://doi.org/10.1080/00207543.2025.2571203 The accepted mansucript may differ from the final published version.Despite many promises ...
Terrenoir, Laurent, Laguna Salvadó, Laura, Merlo, Christophe, Arjunan, Arun, Lartigau, Julie   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Prediction of Failure Due to Fatigue of Wire Arc Additive Manufacturing-Manufactured Product

Currently, the focus of production is shifting towards the use of innovative manufacturing techniques and away from traditional methods. Additive manufacturing technologies hold great promise for creating industrial products. The industry aims to enhance
Andrey Kurkin, Julia Mordovina, Maksim Anosov, Dmitrii Shatagin, Mikhail Chernigin, Sergei Mancerov   +5 more
core   +1 more source

Why education and training in the field of additive manufacturing is a necessity : the right way to teach students and professionals

, 2017
Complexity for free? This is one of the big advantages of additive manufacturing. But what does that mean in reality? In the case of additive manufacturing freedom in general is also a new restriction.
Kirchheim, Andreas, Zumofen, Livia, Dennig, Hans-Jörg, Andreas Kirchheim, Hans-Jörg Dennig, Livia Zumofen   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Synergistic effects in hydrodynamic cavitation abrasive finishing for internal surface-finish enhancement of additive-manufactured components

, 2020
Surface finishing additive-manufactured (AM) internal channels is challenging. In this study, a novel hydrodynamic cavitation abrasive finishing (HCAF) technique is proposed and its feasibility for surface finishing is analyzed.
S.H. Yeo, Yeo, Swee Hock, Arun Prasanth Nagalingam, Yuvaraj, Hemanth Kumar, Nagalingam, Arun Prasanth, Hemanth Kumar Yuvaraj   +5 more
core   +1 more source