Results 81 to 90 of about 4,060,088 (305)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Bulletin of Texas Technological College Vol. 41 No. 3. [PDF]

open access: yes, 1965
The PDF for the March, 1965, course catalog for Texas Technological College is 73 pages ...
Texas Technological College.
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Charting new waters in higher education institutes: navigating the role of technological universities in Ireland and Europe [PDF]

open access: yes
The higher education sector in Ireland is described. Changes in that sector during the period from 1960 to the current time are outlined and discussed.
Griffin, James, Collins, James
core  

Bulletin of Texas Technological College Vol. 41 No. 4. [PDF]

open access: yes, 1965
The PDF for the April, 1965, course catalog for Texas Technological College is 427 pages ...
Texas Technological College.
core  

Efficient electrochemical performance of asymmetric supercapacitor based on nitrogen-doped Nb2CTx MXene in an alkaline electrolyte

open access: yesNano Research Energy
The versatile, and tunable surface chemistry of two-dimensional (2D) MXenes coupled with their distinct properties including hydrophilic nature, favorable ion transport and metallic conductivity make them an ideal candidate for energy storage devices ...
Arooma Syed   +7 more
doaj   +1 more source

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