Results 161 to 170 of about 668,692 (311)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

AI is turning research into a scientific monoculture. [PDF]

Commun Psychol
Traberg CS, Roozenbeek J, van der Linden S.   +2 more
europepmc   +1 more source

Precaution and protection policies of urban ecosystem in the Iblea north eastern coast of Sicily [PDF]

According to the hypothetical urban scenarios in the future, the urban ecosystem will be the piace where the most part of people live, with a deep negative impact on the world ecosystem. So it is necessary for all the people to get better ways of life in
Carmelo Maria Porto, Caterina Cirelli, Enrico Domenico Nicosia, Leonardo Mercatanti   +3 more
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Pathways, prevention, and patient counseling. [PDF]

Neth Heart J
van der Harst P.
europepmc   +1 more source

The Gravity of R&D FDIs. [PDF]

The negative effect of distance is justified by the existence of transport costs which hamper the international exchange of final and intermediate goods, and by higher uncertainty about local markets.
Alfredo Jimenez Palmero, Antonello Zanfei, Davide Castellani   +2 more
core  

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The manufacture of the Baskerville typographic punches: the versatile <i>chaîne opératoire</i> of an 18^th-century printing workshop. [PDF]

NPJ Herit Sci
Montes-Landa J, Box M, Archer-Parré C, Carey AM, Pawlikowski M, Martinón-Torres M.   +5 more
europepmc   +1 more source

The Effects of Product Ageing on Demand: The Case of Digital Cameras [PDF]

The static differentiated product demand model when applied to products with rapid product turnover and declining prices, yields implausible results. One response is to explicitly model the inter-temporal choices of consumers but computational demands ...
Lou, Weifang, Prentice, David, Yin, Xiangkang   +2 more
core   +1 more source

Technology choice & income distribution [PDF]

World Development, 1997
James, M.J., Khan, H.
openaire   +1 more source