Results 61 to 70 of about 464,632 (268)

Information Basis to Assess Russian Technological Security: Problems and Solutions

Мир новой экономики
In this study we continue the research on the main indicators of Russia’s technological security assessment. In previous study we identified and outlined the main vulnerabilities in the information base for assessing technological development.
N. M. Abdikeev, V. V. Narbut
doaj   +1 more source

Understanding Technology Development

Development and Change, 1993
ABSTRACTThere are wide variations between the developing countries in the capabilities of their enterprises to import, utilize and improve upon industrial technologies. It is important for the purposes of industrial policy to understand why these differences exist and how industrial capabilities may be improved.
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Upregulation of ERK-EGR1-heparanase axis by HDAC inhibitors provides targets for rational therapeutic intervention in synovial sarcoma

Journal of Experimental & Clinical Cancer Research, 2021
Background Synovial sarcoma (SS) is an aggressive soft tissue tumor with limited therapeutic options in advanced stage. SS18-SSX fusion oncogenes, which are the hallmarks of SS, cause epigenetic rewiring involving histone deacetylases (HDACs).
Cinzia Lanzi, Enrica Favini, Laura Dal Bo, Monica Tortoreto, Noemi Arrighetti, Nadia Zaffaroni, Giuliana Cassinelli   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Value of inversion imaging to diagnosis in differentiating malignant from benign breast masses

BMC Medical Imaging, 2023
Background We aimed to evaluate the added value of inversion imaging in differentiating between benign and malignant breast masses when combined with the Breast Imaging Reporting and Data System (BI-RADS).
Na Li, Zhongguang Hou, Jiajia Wang, Yu Bi, Xiabi Wu, Yunyun Zhan, Mei Peng   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Concurrent lumbar degenerative disease is independently associated with chronic post-surgical pain after total knee arthroplasty for knee osteoarthritis: a retrospective study

BMC Surgery
Objective Chronic post-surgical pain (CPSP) after total knee arthroplasty (TKA) remains a significant clinical challenge. This study aimed to investigate the association between concurrent lumbar degenerative disease (LDD) and CPSP after TKA for knee ...
Xichen Zhang, Xinfei Zhu, Dunliang Rao, Lei Sha, Liang Hao, Shouhai Jiang, Ziyang Zhang, Chuankai Zhang   +7 more
doaj   +1 more source

Comparative Analysis of Techniques for Texture Feature Extraction for Supervised Classification of Wood and Textile Waste

Recycling
Municipal Solid Waste (MSW) is a common problem in all cities worldwide; it is expected to increase to 3400 billion tons by 2050. In Mexico, an average of 108,146 tons of MSW are generated daily.
Wilfrido Campos Francisco, Jonathan Villanueva Tavira, Jonathan Jesús Carranza Vega, Blanca Dina Valenzuela Robles, Erik Rosado Tamariz, Andrés Blanco Ortega   +5 more
doaj   +1 more source