Results 81 to 90 of about 464,632 (268)

Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria

Nanomaterials, 2019
Development of antimicrobial nanomaterials is one of the most attractive strategies for eliminating the major threat of pathogenic bacteria to public health.
Yanmei Zhang, Xin Zhang, Jie Song, Liming Jin, Xiaotong Wang, Chunshan Quan   +5 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Characterization and mitigation of artifacts derived from NGS library preparation due to structure-specific sequences in the human genome

BMC Genomics
Background Hybridization capture-based targeted next generation sequencing (NGS) is gaining importance in routine cancer clinical practice. DNA library preparation is a fundamental step to produce high-quality sequencing data.
HuiJuan Chen, YiRan Zhang, Bing Wang, Rui Liao, XiaoHong Duan, ChunYan Yang, Jing Chen, YanTong Hao, YingShuang Shu, LiLi Cai, Xue Leng, Nian-Song Qian, DaWei Sun, Beifang Niu, Qiming Zhou   +14 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Two-component system RstAB promotes the pathogenicity of adherent-invasive Escherichia coli in response to acidic conditions within macrophages

Gut Microbes
Adherent-invasive Escherichia coli (AIEC) strain LF82, isolated from patients with Crohn’s disease, invades gut epithelial cells, and replicates in macrophages contributing to chronic inflammation.
Ting Yao, Xingmei Liu, Dan Li, Yu Huang, Wen Yang, Ruiying Liu, Qian Wang, Xueping Li, Jiarui Zhou, Chen Jin, Yutao Liu, Bin Yang, Yu Pang   +12 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Synergistic Neuroprotective and Immunomodulatory Effects of Cocoa Seed Husk and Guarana Extract: A Nutraceutical Approach for Parkinson’s Disease Management

Antioxidants
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder linked to oxidative stress, mitochondrial dysfunction, and neuroinflammation.
Vitória Farina Azzolin, Verônica Farina Azzolin, Euler Esteves Ribeiro, Juliane Santiago Sasso, Douglas Reis Siqueira, Nathalia Cardoso de Afonso Bonotto, Bárbara Osmarin Turra, Marco Aurélio Echart Montano, Ednea Aguiar Maia Ribeiro, Raquel de Souza Praia, Maria Fernanda Mânica-Cattani, Cristina Maranghello, Railla da Silva Maia, Erickson Oliveira dos Santos, Pedro Luis Sosa Gonzalez, Cleideane Cunha Costa, Vanusa Nascimento, Fernanda Barbisan, Ivana Beatrice Mânica da Cruz   +18 more
doaj   +1 more source

Gene and Blood Analysis Reveal That Transfer from Brackish Water to Freshwater Is More Stressful to the Silverside Odontesthes humensis

Frontiers in Genetics, 2018
Silversides are fish that inhabit marine coastal waters, coastal lagoons, and estuarine regions in southern South America. The freshwater (FW) silversides have the ability to tolerate salinity variations.
Tony L. R. Silveira, Gabriel B. Martins, William B. Domingues, Mariana H. Remião, Bruna F. Barreto, Ingrid M. Lessa, Lucas Santos, Danillo Pinhal, Odir A. Dellagostin, Fabiana K. Seixas, Tiago Collares, Ricardo B. Robaldo, Vinicius F. Campos   +12 more
doaj   +1 more source