Results 121 to 130 of about 2,764,306 (262)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Positioning Accountability in European Governance: an Introduction [PDF]

, 2010
The special issue of which this paper forms the introduction takes as its central focus one particular aspect of democratic governance: accountability.
Mair, P., Curtin, D.M., LS International and European Governance, UU LEG Research USG Public Matters Public Governance and Management, Papadopoulos, I.   +4 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evolution logic of urban spatial growth governance and its enlightenment in China: From a perspective of spatial governance

Journal of Urban Management
As the governance modernization and new-type urbanization deepens, China's urbanization process is gradually entering the ''second half''. Understanding the policy practices and transformation logic of China's urban spatial growth in a systematic ...
Ju He, Yongzhong Tan
doaj   +1 more source

Collaborative governance: framing New Zealand practice [PDF]

, 2013
Collaborative governance is talked about as something New Zealand needs to have more of, to deal with the sorts of issues governement faces today, like solving use and conservation of fresh water.
Elizabeth Eppel
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Marine New Quality Productive Forces Empower Marine Environmental Governance: Theoretical Logic, Key Issues and Future Path

Haiyang Kaifa yu guanli
Enhancing the comprehensive capacity of marine environmental governance holds significant implications for the construction of a maritime power and the promotion of sustainable development of the marine economy.
QUAN Yongbo, JIN Jilan
doaj  

Do debt financing, tech-driven transformation and corporate governance enhance or constrain financial reporting quality? Evidence from China

Cogent Economics & Finance
This study investigates how debt financing and technological advancement moderate the relationship between board-level corporate governance mechanisms and earnings management (EM) in Chinese listed financial firms.
Ummar Faruk Saeed, Abdul-Karim Mohammed
doaj   +1 more source

Towards a diversification of Flood Risk Management in Europe: an exploration of governance challenges [PDF]

, 2014
In order to make European regions more resilient to flood risks a broadening of Flood Risk Management strategies (FRMSs) might be necessary. The development and implementation of FRMSs like risk prevention, flood defence, mitigation, preparation and ...
Dieperink, C., Bakker, M.H.N., Driessen, P.P.J., Environmental Governance, Hegger, D.L.T.   +4 more
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