Results 111 to 120 of about 2,764,306 (262)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Does the Use of ICT Enhance the Effectiveness of Rural Governance in China: An Empirical Evidence

SAGE Open
Rural governance is the cornerstone of national governance and essential for modernizing grassroots democratic governance. The ongoing development of ICT has reshaped how farmers exchange information and interact socially, fostering innovations in rural ...
Fan Chen, Miaoyuan Zhong, Suwei Gao, Yani Zhang   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Editorial: Entering the Second Decade; Rethinking Smart Cities and Regional Development

Smart Cities and Regional Development Journal
Marking the beginning of its tenth volume, Smart Cities and Regional Development reflects on a decade of interdisciplinary research at the intersection of technology, governance, and sustainable urban transformation.
Catalin Vrabie
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Co-Evolution of Artificial Intelligence and Green Technological Innovation: A Computational Mapping and Diagnostic Framework

Analytics
Artificial intelligence (AI) is increasingly recognised for its transformative implications for sustainability transitions. Yet little is known about how AI co-evolves with green technological innovation systems and whether institutional adaptation keeps
Chong Guan, Jing Ren, Tristan Lim
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Corporate climate governance drives environmental innovation under policy and resource perspectives

Discover Sustainability
Given the substantial risks posed by climate change and environmental challenges, firms are increasingly adopting climate governance strategies. This study, grounded in resource-based view and institutional theory, examines the relationship between ...
Yijing Liang, Dechao Ma
doaj   +1 more source

Towards a diversification of Flood Risk Management in Europe: a reflection on meta-governance challenges [PDF]

, 2014
Because of climate change, extreme weather events and urban sprawl, urban areas have to deal with increasing flood risks. It is argued, both in literature and in practice that these risks can no longer be dealt with by focusing solely on flood defences ...
Dieperink, C., Bakker, M.H.N., Driessen, P.P.J., Environmental Governance, Hegger, D.L.T.   +4 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source