Results 91 to 100 of about 526,015 (308)
Urban ScienceCities are increasingly expected to achieve environmentally sustainable outcomes while simultaneously adapting to rapid technological transformation and growing governance complexity.
Khoren Mkhitaryan +4 more
doaj +1 more source
Trade Liberalization, Outsourcing, and Firm Productivity [PDF]
Empirical evidence suggests that trade liberalization increases firm productivity. This paper offers a novel explanation for this finding. I develop a simple general equilibrium model of trade in which trade liberalization leads to outsourcing as firms ...
Ralph Ossa
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Yixue yu zhexueAt present, nations are engaged in the ethical governance research of gene editing technologies. However, effective dialogue and the establishment of a unified international governance framework remain elusive.
Rui CHENG, Qiqin FU
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The financing and governance of new technologies [PDF]
, 2004 This paper examines the financial sector preconditions for the successful development of high technology sectors. It argues that there is a close relation between types of activities undertaken in different countries and their institutional structures.
openaire +3 more sources
The Global Risks Report 2016, 11th Edition [PDF]
, 2016 Now in its 11th edition, The Global Risks Report 2016 draws attention to ways that global risks could evolve and interact in the next decade. The year 2016 marks a forceful departure from past findings, as the risks about which the Report has been ...
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Navigating the Ethical Landscape of AI Innovation: Challenges and Opportunities
International Journal of Digital Law and GovernanceThe rapid development of Artificial Intelligence (AI) is reshaping the global landscape; however, this progress has concurrently given rise to a series of profound ethical and legal challenges.
Mao Qiyan, Xu Ming
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Blockchain in the Government Technology Fabric
CoRR, 2019 Fuelled by the success (and hype) around cryptocurrencies, distributed ledger technologies (DLT), particularly blockchains, have gained a lot of attention from a wide spectrum of audience who perceive blockchains as a key to carry out business processes that have hitherto been cumbersome in a cost and time effective manner. Governments across the globe
openaire +2 more sources