Results 81 to 90 of about 526,015 (308)

Evolving into a Regional Innovation System: How Governance impact on Innovation in Shenzhen and Dongguan, China? [PDF]

Governance constitutes elementary supportive infrastructure for regional innovation systems. This paper extends the evolutionary lens of governance into initial industrialization phase and examines the impact of their evolution into regional innovation ...
Daniel Schiller, Javier Revilla Diez, Wenying Fu   +2 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Does the Use of ICT Enhance the Effectiveness of Rural Governance in China: An Empirical Evidence

SAGE Open
Rural governance is the cornerstone of national governance and essential for modernizing grassroots democratic governance. The ongoing development of ICT has reshaped how farmers exchange information and interact socially, fostering innovations in rural ...
Fan Chen, Miaoyuan Zhong, Suwei Gao, Yani Zhang   +3 more
doaj   +1 more source

Evolution logic of urban spatial growth governance and its enlightenment in China: From a perspective of spatial governance

Journal of Urban Management
As the governance modernization and new-type urbanization deepens, China's urbanization process is gradually entering the ''second half''. Understanding the policy practices and transformation logic of China's urban spatial growth in a systematic ...
Ju He, Yongzhong Tan
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Science and Technology in Government [PDF]

Science, 1993
R S, Nicholson, P H, Abelson
openaire   +2 more sources

Total factor productivity growth in European stock exchanges: A non-parametric frontier approach [PDF]

This paper examines progressive changes in productivity of the European stock exchange industry using non-parametric frontier techniques. Within the framework of Malmquist indices, total factor productivity growth is decomposed into technological ...
Schmiedel, Heiko
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Do debt financing, tech-driven transformation and corporate governance enhance or constrain financial reporting quality? Evidence from China

Cogent Economics & Finance
This study investigates how debt financing and technological advancement moderate the relationship between board-level corporate governance mechanisms and earnings management (EM) in Chinese listed financial firms.
Ummar Faruk Saeed, Abdul-Karim Mohammed
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source