Results 81 to 90 of about 1,235,212 (309)
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
What do we really know about when technological innovation improves performance (and when it does not)? [PDF]
Most approaches to innovation bear the implicit assumption that increased innovativeness leads to improved organizational performance. Thus, more attention has been focused on innovativeness than on innovation performance; on novelty than on value ...
Adegbesan, Tunji, Ricart, Joan E.
core
Towards Principled Responsible Research and Innovation: Employing the Difference Principle in Funding Decisions [PDF]
, 2015 Responsible Research and Innovation (RRI) has emerged as a science policy framework that attempts to import broad social values into technological innovation processes whilst supporting institutional decision-making under conditions of uncertainty and ...
Brownlie Ian +11 more
core +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Asian Journal of Technology Management, 2012 This study analyzed the determinants of technological innovation in the Malaysian manufacturing industry. Its main purpose is to identify a set of management- related variables characterizing Malaysian innovative firms.
Amlus Ibrahim +3 more
doaj +2 more sources
Journal of Innovation & KnowledgeThis study employs the panel smooth threshold autoregression model to data spanning 27 European Union (EU) member states from 2000 to 2022 to investigate the nonlinear relationships between green growth and green technological innovation.
Afef BOUATTOUR +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Managing interactions between technological and stylistic innovation in the media industries, insights from the introduction of ebook technology in the publishing industry [PDF]
The mainstream of innovation research pays a lot of attention to technological innovation, but has neglected its interaction with another type of innovation, which is particularly important in sectors like the furniture, fashion and the media content ...
Schweizer, T.S.
core +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source