Results 51 to 60 of about 47,818 (311)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Мир новой экономикиThe relevance of this study is driven by the critical importance of developing high-tech and knowledge-intensive industries for the Russian economy.
A. E. Sergeeva
doaj +1 more source
ASCILITE Publications, 2010 This paper uses a grounded theory approach to derive key findings from 12 empirical studies on technology leadership. Roles of technology leaders were identified and categorized into four main areas of change: infrastructural, organizational structure and policy, pedagogical, and cultural change.
openaire +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Globally-Minded Leadership: A New Approach for Leading Schools in Diverse Democracies
, 2019 Global migration, global markets, and technological advances have connected the world at an unprecedented scale and have diversified the communities with which people engage and the schools in which educators teach.
Tichnor-Wagner, Ariel
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Assessing the effectiveness of digital transformation of regional economic systems
π-EconomyIn the modern economic paradigm, digital transformation has established itself as a key driver of socio-economic development in territories. However, its outcomes demonstrate significant variability, driven by disparities in the availability of financial
Dinmukhametova Aliya
doaj +1 more source
Leadership as a determinant of innovative behaviour [PDF]
In knowledge-intensive services innovative behaviour of co-workers is a critical success factor. In sectors like consultancy, research and architecture the nature of the work implies that projects are never alike.
Jeroen de Jong, Deanne den Hartog
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source