Results 191 to 200 of about 245,064 (314)

Small Business Innovation Research : Program Solicitation (Closing Date : May 1, 1997)

The Small Business Innovation Research (SBIR) Program is the primary vehicle through which the federal government funds research and development (R&D) projects at small technology companies.
John A. Volpe National Transportation Systems Center (U.S.)
core  

A hybrid in-person and online group singing program for older adults with breathing limitations: A pilot mixed-methods study. [PDF]

Can J Respir Ther
Marquis N, Tanguay P, Drouin L, Gosine J, Couturier Y, Martel-Sauvageau V, Provencher V.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Competency Framework for Medical AI Education: Mixed Methods Study. [PDF]

JMIR Med Educ
Cai C, Zhu G, Zhou SM, Ng O, Duell J, Ho WK, Chen DM, Lee B, Li F, Liu S, Sudarshan V, Wang LR, Choi C, Fan X.   +13 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Metabolomics and ultra-processed foods intake: A scoping review protocol. [PDF]

MethodsX
Peixoto TDN, Rocha ALMA, Pedrosa LFC.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Coding-complete genome sequence of a largemouth bass virus isolate from <i>Micropterus salmoides</i> collected in China. [PDF]

Microbiol Resour Announc
He H, Huang H, Zhang Y, Yang X, Yi M, Jia K.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Bionic sleep therapy for refractory insomnia: a case report and literature review. [PDF]

BMC Anesthesiol
Xiao QX, Zhu SY, Ma YY, Zhao PC, Chen HX, Bao YJ, Lei JM, Wang L, Zhou H, Ma RX, Xiong LL.   +10 more
europepmc   +1 more source