Results 111 to 120 of about 653,731 (310)

Scientific culture from the University. Research competence evaluation of students enrolled in the Summer Science Programs

Education in the Knowledge Society, 2017
The training of young researchers from tertiary education represents a latent concern in educational centers worldwide. In that sense, there are private and public initiatives that encourage scientific culture inside and outside the school curriculum ...
Abel Antonio GRIJALVA VERDUGO, María Luisa Urrea ZAZUETA   +1 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Professor Stefan Czarnecki

Archives of Acoustics, 2014
On September 1-st 2007 it would have been 25 years from the death of Professor Stefan Czarnecki, a well-known Polish acoustic engineer. Some of his achievements should be reminded here.
Zbigniew W. ENGEL
doaj  

The U.S. Science and Engineering Workforce: Recent, Current, and Projected Employment, Wages, and Unemployment [PDF]

, 2013
[Excerpt] As Congress develops policies and programs and makes appropriations to help address the nation’s needs for scientists and engineers, it may wish to consider past, current, and projected S&E workforce trends. In this regard, this report provides
Sargent, John F, Jr.
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dissonance in the Algorithmic Era: Evaluating Showcase Digital Competence and Ethical Resilience in Communication Training

Journalism and Media
The disruptive acceleration of Generative Artificial Intelligence (GAI) has amplified the phenomenon of Global Friction (Globofriction), where technological speed undermines informational stability and weakens democratic resilience.
Esma Kucukalic Ibrahimovic
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Smart connected farms and networked farmers to improve crop production, sustainability and profitability

Frontiers in Agronomy
To meet the grand challenges of agricultural production including climate change impacts on crop production, a tight integration of social science, technology and agriculture experts including farmers are needed.
Asheesh K. Singh, Behzad J. Balabaygloo, Barituka Bekee, Samuel W. Blair, Suzanne Fey, Fateme Fotouhi, Ashish Gupta, Amit Jha, Jorge C. Martinez-Palomares, Kevin Menke, Aaron Prestholt, Vishesh K. Tanwar, Xu Tao, Anusha Vangala, Matthew E. Carroll, Sajal K. Das, Guilherme DePaula, Peter Kyveryga, Soumik Sarkar, Michelle Segovia, Simone Silvestri, Corinne Valdivia   +21 more
doaj   +1 more source

Mechanistic action of weak acid drugs on biofilms

Scientific Reports, 2017
Selective permeability of a biofilm matrix to some drugs has resulted in the development of drug tolerant bacteria. Here we studied the efficacy of a weak organic acid drug, N-acetyl-L-cysteine (NAC), on the eradication of biofilms formed by the mucoid ...
Binu Kundukad, Megan Schussman, Kaiyuan Yang, Thomas Seviour, Liang Yang, Scott A. Rice, Staffan Kjelleberg, Patrick S. Doyle   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source