Results 51 to 60 of about 80,011 (312)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
RUSSIAN EXPERIENCE IN ENGINEERING EDUCATION DEVELOPMENT
Высшее образование в России, 2018 The implementation of the large-scale system program devoted to the development of a new technological generation economy announced by the President of Russia V.V. Putin in his Address to the Federal Assembly of the Russian Federation on December 1, 2016
A. I. RUDSKOY +2 more
doaj
Efficacy of Emerging Technologies to Manage Childhood Obesity
Diabetes, Metabolic Syndrome and Obesity, 2022 Mohammad Alotaibi,1 Fady Alnajjar,2 Massimiliano Cappuccio,3 Sumaya Khalid,2 Tareq Alhmiedat,1,4 Omar Mubin5 1Faculty of Computers and Information Technology, University of Tabuk, Tabuk, Saudi Arabia; 2College of Information Technology, United Arab ...
Alotaibi M +5 more
doaj
Fellowship of the Australian Academy of Technological Sciences and Engineering, 1996
, 1996 Associate Professor Derry Doyle, Materials Technology Laboratory, has been elected to the Fellowship of the Australian Academy of Technological Sciences and Engineering, a peak body of eminent scientists and engineers.
Swinburne University of Technology
core
How Science is applied in Technology: Explaining Basic Sciences in the Engineering Sciences [PDF]
, 2004 The issue of this oral presentation is “How Science is applied in Technology”; more specifically, how science is used in developing knowledge of phenomena and processes that occur in technological devices.
Boon, Mieke
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source