Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Cumulative causation in the formation of a technological innovation system: The case of biofuels in the Netherlands [PDF]
Despite its worldwide success, the innovation systems approach is often criticized for being theoretically underdeveloped. This article aims to contribute to the conceptual and methodical basis of the (technological) innovation systems approach.
Roald A.A. Suurs, Marko P. Hekkert
core
PARAMETRIC SYNTHESIS OF MODELS FOR MULTICRITERIAL ESTIMATION OF TECHNOLOGICAL SYSTEMS
Сучасний стан наукових досліджень та технологій в промисловості, 2017 The subject matter of the article is the problem of multicriteria estimation of the properties of technological systems (TS) in the process of their structural-parametric optimization. The goal of the study is to increase the efficiency of procedures for
Vladimir Beskorovainyi
doaj +1 more source
Influence of the Compliance of a Technological System on the Machining Accuracy of Low-Stiffness Shafts in the Grinding Process. [PDF]
Materials (Basel), 2023 Świć A, Gola A.
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Improvement in Quality of Life With the Use of a Technological System Among Patients With Chronic Disease Followed Up in Primary Care (TeNDER Project): Protocol for a Randomized Controlled Trial. [PDF]
JMIR Res Protoc, 2023 Lozano Hernández CM +10 more
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Influence of demand patterns on the optimal orientation of photovoltaic systems [PDF]
, 2017 Photovoltaic (PV) systems are usually orientated to maximize annual energy yield. This may not optimize other system indicators, specifically: direct consumption of self-generated PV power, reduced feed-in power and annual revenue. Also, these indicators
Litjens, G. B.M.A. +8 more
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Determination of geometrical parameters of the diamond gear hones for the finishing of gears
Mechanics and Advanced Technologies, 2019 The formation of the service properties of the gears occurs at the stages of their finishing using processes such as gear grinding, shaving, gear honing, lapping, etc.
Michael Storchak, Yuriy Danylchenko
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source