Results 31 to 40 of about 137,653 (268)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Technology Capital Transfer [PDF]

, 2011
It is widely believed that an important factor underlying the rapid growth in China is increased foreign direct investment (FDI) and the transfer of foreign technology capital, which is accumulated know-how from investment in research and development (R\&D), brands, and organizations that is not specific to a plant. In this paper, we study two channels
Thomas J. Holmes, Ellen R. McGrattan, Edward C. Prescott   +2 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Technology Transfer: What to Transfer?

IFAC Proceedings Volumes, 1979
Abstract In this paper, proper technology transfer is viewed as a transfer of not only production capabilities but also of methodologies and scientific understanding upon which such capabilities are based. The author discusses different forms, criteria for selection and evaluation systems, and bases for proper and sound decisions.
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Health technology transfer

BMJ, 2000
Global health relies on biomedical scientists and public health workers to solve infectious disease and other health problems at a local level. Yet investigators in developing countries face tremendous obstacles; scientific isolation, insufficient technical training and research tools, a lack of up to date scientific information, and limited financial,
E, Harris, M, Tanner
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Building Integrated Photovoltaics (BIPV): Analysis of the Technological Transfer Process and Innovation Dynamics in the Swiss Building Sector

Buildings
Solar has confirmed its dominance among all power generation technologies, and along with the demand for zero-emission buildings, Photovoltaics (PV) is contributing to transforming the building skin.
Pierluigi Bonomo, Francesco Frontini
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Numerical Simulation of High-Density Ratio Bubble Motion with interIsoFoam

Fluids, 2022
The breeding blanket is one of the fundamental components of a nuclear fusion reactor and is responsible for the fuel production, generating tritium through neutronic capture reaction between lithium and neutrons.
Simone Siriano, Néstor Balcázar, Alessandro Tassone, Joaquim Rigola, Gianfranco Caruso   +4 more
doaj   +1 more source