Results 61 to 70 of about 5,155,074 (299)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Pooled testing with replication as a mass testing strategy for the COVID-19 pandemics

Scientific Reports, 2021
During the COVID-19 pandemic it is essential to test as many people as possible, in order to detect early outbreaks of the infection. Present testing solutions are based on the extraction of RNA from patients using oropharyngeal and nasopharyngeal swabs,
Julius Žilinskas, Algirdas Lančinskas, Mario R. Guarracino   +2 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

QA-RAG: Exploring LLM Reliance on External Knowledge

Big Data and Cognitive Computing
Large language models (LLMs) can store factual knowledge within their parameters and have achieved superior results in question-answering tasks. However, challenges persist in providing provenance for their decisions and keeping their knowledge up to ...
Aigerim Mansurova, Aiganym Mansurova, Aliya Nugumanova   +2 more
doaj   +1 more source

Data science and data technology

, 2017
The big buzz over the past few years has been Data Science. Corporations are opening Data Science departments and staffing them with PhDs, and universities have started Data Science programs to sell credentials for these jobs. As a linguist I’m particularly interested in this new field, because it includes research practices that I’ve been using for ...
openaire   +1 more source

X.509 certificate error testing [PDF]

, 2018
X.509 Certificates are used by a wide range of technologies to verify identities, while the SSL protocol is used to provide a secure encrypted tunnel through which data can be sent over a public network.
Jimenez M., Momani E. M. H., Toma C
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Enhancing credit card fraud detection: highly imbalanced data case

Journal of Big Data
In the contemporary landscape, fraud is a widespread challenge in today’s financial landscape, requiring innovative methods and technologies to detect and prevent losses from the sophisticated tactics used by fraudsters.
Dalia Breskuvienė, Gintautas Dzemyda
doaj   +1 more source

Global Embeddings, Local Signals: Zero-Shot Sentiment Analysis of Transport Complaints

Informatics
Public transport agencies must triage thousands of multilingual complaints every day, yet the cost of training and serving fine-grained sentiment analysis models limits real-time deployment.
Aliya Nugumanova, Daniyar Rakhimzhanov, Aiganym Mansurova   +2 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source