Results 31 to 40 of about 26,384 (312)

Noninvasive NMR/MRS Metabolic Parameters to Evaluate Metabolic Syndrome in Rats

Diagnostics, 2022
(1) Background: Ectopic fat deposition and its effects, metabolic syndrome, have been significantly correlated to lifestyle and caloric consumption. There is no specific noninvasive evaluation tool being used in order to establish clinical markers for ...
Khin Thandar Htun, Krit Jaikumkao, Jie Pan, Aye Thidar Moe Moe, Nuttawadee Intachai, Sasivimon Promsan, Anusorn Lungkaphin, Monruedee Tapanya, Duanghathai Pasanta, Montree Tungjai, Siriprapa Kaewjaeng, Hong Joo Kim, Jakrapong Kaewkhao, Christopher Lai, Suchart Kothan   +14 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Assessments of Medical Student’s Knowledge About Radiation Protection and Different Imaging Modalities in Jeddah, Saudi Arabia

International Journal of Biomedical Imaging
Conclusions: The assessments of medical students’ knowledge regarding radiation exposure in diagnostic modalities reveal a low level of confidence in their knowledge of ionizing radiation dose parameters. Furthermore, the mean scores on overall knowledge
Raghad Aljondi, Rahaf Alem, Rowa Aljondi, Abdulrahman Tajaldeen, Salem Saeed Alghamdi, Mohammed Majdi Toras   +5 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Recent methods for the diagnosis and differentiation of ameloblastoma: a narrative review

All Life
Ameloblastoma is a benign but locally invasive tumour. Early diagnosis of ameloblastoma and formulating an appropriate treatment plan play a crucial role in reducing the postoperative recurrence rate.
Ke Hu, Xudong Zhang, Ruixue Chen, Xiangjun Li   +3 more
doaj   +1 more source

Pentagalloyl Glucose-Targeted Inhibition of P-Glycoprotein and Re-Sensitization of Multidrug-Resistant Leukemic Cells (K562/ADR) to Doxorubicin: In Silico and Functional Studies

Pharmaceuticals, 2023
Combining phytochemicals with chemotherapeutic drugs has demonstrated the potential to surmount drug resistance. In this paper, we explore the efficacy of pentagalloyl glucose (PGG) in modulating P-gp and reversing multidrug resistance (MDR) in drug ...
Nathupakorn Dechsupa, Nopawit Khamto, Pornthip Chawapun, Sadanon Siriphong, Phattarawadee Innuan, Authaphinya Suwan, Thitiworada Luangsuep, Nichakorn Photilimthana, Witchayaporn Maita, Rossarin Thanacharttanatchaya, Padchanee Sangthong, Puttinan Meepowpan, Chatchanok Udomtanakunchai, Jiraporn Kantapan   +13 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Iron–quercetin complex reprograms tumor-associated macrophages toward M1 phenotype and enables MRI tracking in ex vivo tumor-mimicking spheroids

Cancer Nanotechnology
Background Tumor-associated macrophages (TAMs) frequently adopt an M2-like, immunosuppressive state that promotes tumor growth and therapy resistance. Reprogramming TAMs toward a pro-inflammatory M1 phenotype is a promising strategy to remodel the tumor ...
Nathupakorn Dechsupa, Phattarawadee Innuan, Waqas Ihsan, Cherdphong Korbuakesorn, Kawinna Siri, Pimwipa Tepinta, Pitchayapon Ariyawatkul, Rattawish Khamphorn, Saran Phohiran, Chengli Wen, Witida Laopajon, Jiraporn Kantapan   +11 more
doaj   +1 more source

Two cases of hemodynamic improvement by modulation of atrioventricular delay in cardiac operations

JA Clinical Reports, 2022
Background Symptomatic sick sinus syndrome is one of the indications for pacemaker implantation, and we have to consider to program the pacemaker to an asynchronous pacing mode during an operation. Case presentation We reported two cases with a pacemaker
Akiko Tomita-Kobayashi, Tomoko Fujimoto, Shoko Takada, Yuki Masuda, Akinobu Mizutani, Yukio Hayashi   +5 more
doaj   +1 more source