Results 31 to 40 of about 8,651,942 (310)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Iron–quercetin complex reprograms tumor-associated macrophages toward M1 phenotype and enables MRI tracking in ex vivo tumor-mimicking spheroids

Cancer Nanotechnology
Background Tumor-associated macrophages (TAMs) frequently adopt an M2-like, immunosuppressive state that promotes tumor growth and therapy resistance. Reprogramming TAMs toward a pro-inflammatory M1 phenotype is a promising strategy to remodel the tumor ...
Nathupakorn Dechsupa, Phattarawadee Innuan, Waqas Ihsan, Cherdphong Korbuakesorn, Kawinna Siri, Pimwipa Tepinta, Pitchayapon Ariyawatkul, Rattawish Khamphorn, Saran Phohiran, Chengli Wen, Witida Laopajon, Jiraporn Kantapan   +11 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Effects of obesity on the lipid and metabolite profiles of young adults by serum 1H-NMR spectroscopy [PDF]

PeerJ, 2019
Background Overweight (OW) is considered a risk for various metabolic diseases. However, its effects as a mechanism that alters the metabolite profiles remain unclear.
Duanghathai Pasanta, Sirirat Chancharunee, Montree Tungjai, Hong Joo Kim, Suchart Kothan   +4 more
doaj   +2 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Two cases of hemodynamic improvement by modulation of atrioventricular delay in cardiac operations

JA Clinical Reports, 2022
Background Symptomatic sick sinus syndrome is one of the indications for pacemaker implantation, and we have to consider to program the pacemaker to an asynchronous pacing mode during an operation. Case presentation We reported two cases with a pacemaker
Akiko Tomita-Kobayashi, Tomoko Fujimoto, Shoko Takada, Yuki Masuda, Akinobu Mizutani, Yukio Hayashi   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

LEARNING PREFERENCES AND COMPETENCIES OF RADIOLOGIC TECHNOLOGY INTERNS ON GENERAL RADIOGRAPHY

, 2021
Radiologic Education has substantially changed throughout the years and has certain advancements that have left the country catching on. It has transitioned from analog to digital imaging, which considerably left developing countries behind. Consequently,
CERBITO, ADONIS F., LAPASTORA, ED, GONZALES, KERWIN PAUL J.   +2 more
core   +2 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

An unusual case of colonic intussusception in old age

Journal of Taibah University Medical Sciences, 2019
الخلاصة: الانغلاف المعوي هو دخول جزء من الأمعاء الى الجزء المجاور منها وهو سبب نادر لانسداد الأمعاء عند الكبار. عادة ياتي المريض وفيه علامات البطن الحاد الذي يشمل مجموعة واسعة من الحلات الطارئة.
Sultan A. Alshoabi, MD, Osamah M. Abdulaal, PhD   +1 more
doaj   +1 more source