Results 61 to 70 of about 21,434,422 (280)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2021 The development of information technology makes it easier for humans to complete work. Work that previously required a lot of manpower to complete can now be completed with the help of technology. As in writing citations, it can be done automatically ...
Nugraha, Jaka, Zahro, Dewi Arrohmatuz
core +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
ACCEPTANCE OF WEB-BASED TECHNOLOGY AS A HARMONIOUS COMMUNITY OF CITIZEN WITH THE CONCEPT OF TECHNOLOGY MODEL ACCEPTANCE [PDF]
, 2019 The internet in this era is a way of communicating the most quickly and effectively in disseminating information. Through the internet, various information can be received using several ways, such as websites, email and others.
Riki, Riki -
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
JPPI (Jurnal Penelitian Pendidikan Indonesia)The use of Virtual Reality (VR) technology in education is growing rapidly, including in the context of Islamic learning. This study aims to examine the acceptance of the VR-based Hadith learning model among students of the Islamic Religious Education ...
Muhammad Luthfi Hamzah +4 more
doaj +1 more source
The influence of technology, environment and user acceptance on the effectiveness of information system project selection using SEM [PDF]
, 2013 The selection of the present information system project is difficult because of the many factors that influence it. Information system project should pay attention to the user acceptance, technology and the environment in terms of their influence on the ...
Johari, Nor Azmi +4 more
core +1 more source