Results 111 to 120 of about 8,497,329 (308)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Addiction and Self-Control: An Intrapersonal Game [PDF]

open access: yes
In their model of addiction, O´Donoghue and Rabin obtain a counterintuitive result: a person that is fully aware of his self-control problems (sophisticate) is more prone to become addicted than one who is fully naware (na¨ıf).
López Rafael
core  

DIGITAL DILEMMA: EXPLORING THE IMPACT OF ELECTRONIC DEVICES ON DEVELOPMENT AND PRACTICAL EDUCATIONAL ALTERNATIVES

open access: yesInternational Journal of Social and Educational Innovation
The increasing presence of electronic devices in the daily lives of children has sparked significant concern regarding their potential impact on various aspects of child development.
Monica TURTUREAN
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Representing Addiction in Contemporary Media [PDF]

open access: yes
openThis thesis explores the multifaceted representations of addiction in various media with the aim of shedding light on the complex socio-cultural implications of these representations.
CHMIELARCZYK, MILENA
core  

Sex Addiction: the Chicken-and-Egg Dilemma of Diagnosis [PDF]

open access: yes, 2013
In May 2013, the American Psychiatric Association will release the next version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Interestingly, sex addiction, despite significant attention from mainstream media, will be omitted from ...
Berry, MD
core  

A revealed preference analysis of the rational addiction model. [PDF]

open access: yes
We provide a revealed preference analysis of the rational addiction model. The revealed preference approach avoids the need to impose an, a priori unverifiable, functional form on the underlying utility function.
Demuynck, Thomas, Verriest, Ewout
core   +2 more sources

Tekno-Oruç Bir Öz Disiplin Pratiği Olabilir mi?

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi
Teknolojinin insan yaşamındaki kontrolsüz varoluşu zaman içerisinde bireyin teknoloji içerisinde hapsolduğu bir ilişkinin ortaya çıkmasına sebep olmuştur.
Ramazan Erdem, Aslı Metin
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

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