Results 141 to 150 of about 7,254,348 (387)
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
International Journal of Social and Educational InnovationThe increasing presence of electronic devices in the daily lives of children has sparked significant concern regarding their potential impact on various aspects of child development.
Monica TURTUREAN
doaj
Selçuk Üniversitesi Sosyal Bilimler Meslek Yüksekokulu DergisiDijital teknolojiler bireylere daha rahat ve verimli bir ortam sağlarken, diğer yandan psikolojik, fiziksel ve sosyal sorunlara neden olmaktadır. Bu olumsuz etkilerden kurtulmak için bireyler geçici de olsa tatil ve seyahatlerinde dijital teknolojilerden
Erkan Akgöz, Feridun Aydınlı
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
ТЕХНОЛОГИЧЕСКАЯ ЗАВИСИМОСТЬ КАК АКТУАЛЬНАЯ ПРОБЛЕМА ОБЩЕСТВЕННОГО ЗДРАВООХРАНЕНИЯ
Cifra: ПсихологияВ статье представлен анализ отечественных и зарубежных исследований в сфере профилактики кибераддиктивных паттернов поведения. Результаты анализа указывают на недостаточный уровень исследовательской базы по данной теме, необходимость дополнительных ...
Попов П.М.
doaj +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Addiction trends: Internet v casino gambling [PDF]
, 2006 Gambling addictions always result from an interaction and interplay between many factors including the person’s biological and/or genetic predisposition, their psychological constitution, their social environment and the nature of the activity itself ...
Griffiths, M
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
SOCIAL MEDIA ADDICTION, WORK TECHNOLOGY CONFLICTS ON TASK PERFORMANCE IN ISLAMIC STUDENTS
Psikis: Jurnal Psikologi IslamiChallenges associated with social media use, such as distractions and reduced focus on academic activities, can negatively impact task performance.
Anisatul Mardiah +6 more
doaj +1 more source