Results 151 to 160 of about 8,497,329 (308)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Addiction and technology: technology in the treatment of smoking
, 2014 More ıand more forms and types of addiction appear as the time passes by as new substances that cause dependence show up, Nevertheless, there are the methods that can be used in the treatment of those forms of addiction. ln recent years, new technology - based methods of facing and treating addiction have made their appearance in addition to the ...
Skevi, Lorena, Skevi, Androniki
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INFORMATION TECHNOLOGIES AS A SERVICE AND ADDICTION [PDF]
International Scientific Journal Monte, 2021 Mefail Tahiri, Ejup Rustemi
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2006 Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years.
Koob, George F., Le Moal, Michel.
core
Editorial: Individual differences in addictive behaviors
Frontiers in PsychologyLucy J. Troup
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DIGITAL ADDICTION AS TECHNOLOGY ADDICTION
TURKISH ONLINE JOURNAL OF DESIGN ART AND COMMUNICATION, 2019 openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Is Addiction "Rational"? Theory and Evidence [PDF]
A standard model of addictive process is Becker and Murphy's rational addiction' model, which has the key empirical prediction that the current consumption of addictive goods should respond to future prices, and the key normative prediction that the ...
Jonathan Gruber, Botond Koszegi
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source