Results 111 to 120 of about 1,536,208 (306)

The diffusion of new technology: adoption subsidies, spillovers, and transaction costs. [PDF]

open access: yes
We establish the relation between optimal subsidy rates and spillovers from the sequential adoption of a new technology, we find that they evolve in the same direction over time. We show that spillovers, hence the subsidy rates, need not be monotonic. We
Chokri Dridi, Naceur Khraief
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Complementarities and differences in adoption: an application of hazard models to two technologies in Madagascar [PDF]

open access: yes
This paper explores the adoption of two agricultural technologies, how their patterns of adoption differ, and the relationship between them. The first technology, the System of Rice Intensification, has been studied previously and high rates of ...
Butler, J.S., Moser, Christine M.
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Adoption Lags, Implementation Gaps, and Economic Growth [PDF]

open access: yes
We introduce a model of endogenous growth in which the returns to innovation are determined by the technology adoption decisions of the users of the new innovative technologies.
Bart Hobijn, Diego Comin
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Technology Adoption in Poorly Specified Environments [PDF]

open access: yes
This article extends the characteristics-based choice framework of technology adoption to account for decisions taken by boundedly-rational individuals in environments where traits are not fully observed.
Useche, Pilar
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Why Blockchain Benefits Don’t Guarantee Adoption: An Integrated TAM-TOE Analysis of Technology Acceptance and Organizational Readiness

open access: yesBlockchain in Healthcare Today
Background: Despite blockchain technology’s demonstrated potential to enhance security, transparency, and efficiency in healthcare systems, adoption rates remain significantly lower than predicted, creating a persistent gap between perceived benefits and
Fatma M. AbdelSalam
doaj   +1 more source

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