Results 41 to 50 of about 374,519 (265)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Human Capital and Technology Diffusion [PDF]

Federal Reserve Bank of San Francisco, Working Paper Series, 2002
This paper generalizes the Nelson-Phelps catch-up model of technology diffusion. We allow for the possibility that the pattern of technology diffusion can be exponential, which would predict that nations would exhibit positive catch-up with the leader nation, or logistic, in which a country with a sufficiently small capital stock may exhibit slower ...
Jess Benhabib, Mark M. Spiegel
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A case for promoting negative emission technologies: learning from renewable energy support

Carbon Management
To achieve net-zero emissions by mid-century, the removal of carbon dioxide from the atmosphere through negative emission technologies (NETs) will play an integral part.
Leonie P. Meissner
doaj   +1 more source

Technology Diffusion and Postwar Growth [PDF]

SSRN Electronic Journal, 2010
In the aftermath of World War II, the world's economies exhibited very dierent rates of economic recovery. We provide evidence that those countries that caught up the most with the U.S. in the postwar period are those that also saw an acceleration in the speed of adoption of new technologies.
Diego A. Comin, Bart Hobijn
openaire   +5 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Impact of Industrial Agglomeration on Environmental Efficiency of China’s Major Freshwater Aquaculture Regions

Fishes
Freshwater aquaculture in China has expanded rapidly in recent decades, raising growing concerns about its environmental sustainability. However, the relationship between industrial agglomeration and environmental efficiency in freshwater aquaculture ...
Qiansheng Wan, Yingli Zhang, Shunxiang Yang, Lewei Peng   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Radiation oncology, five years and beyond: An evidence-and-capital global framework for evaluating six emerging innovations

Visualized Cancer Medicine
Radiation oncology is poised for a decade of unusually rapid technological and biological change. Six innovations are converging on the clinic: FLASH radiotherapy, adaptive radiotherapy with advanced imaging, artificial intelligence and machine learning ...
Miller Robert C.
doaj   +1 more source