Results 41 to 50 of about 79,605 (264)
Energy, Sustainability and Society, 2017 The background of this article is how the challenge to accomplish a sustainable energy transition—in service of various objectives, such as environmental and geopolitical concerns—has recently brought the development of smart heat infrastructures to the ...
Michiel A. Heldeweg +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Southern African Journal of Entrepreneurship and Small Business ManagementBackground: Small, medium and micro enterprises (SMMEs) in the public sector construction are constrained by limited access to large-scale contracts, insufficient capital, and skills development barriers, this mostly being a result of traditional ...
Nonjabulo Ndlovu +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Governing AI’s sustainability: risks, current responses, and pathways for improved governance
Revista Cubana de Administración Pública y EmpresarialArtificial intelligence development presents significant sustainability challenges across environmental, social, and economic dimensions, demanding more coordinated and systematic governance approaches.
Hong Guan +5 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Technological foundations of electronic governance
Proceedings of the 1st international conference on Theory and practice of electronic governance, 2007 This paper explores the relevance and opportunities for the application of mature Formal Techniques - techniques based on mathematical theories and supported by industry-ready tools and methods - to build technical solutions for Electronic Governance. The paper proceeds in four steps: (1) establishes the basic need for Formal Techniques in Electronic ...
Jim Davies +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Government Patenting and Technology Transfer [PDF]
SSRN Electronic Journal, 2006 Intellectual property rights such as patents protect new inventions from imitation and competition. Patents' major objective is to provide incentives for invention, sacrificing short-term market efficiency for long-term economic gains. Although patents are primarily granted to private firms, policy changes over the last 25 years have resulted in ...
Heisey, Paul W. +2 more
openaire +2 more sources