Results 61 to 70 of about 8,629 (213)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Audit Tata Kelola Teknologi Informasi Untuk Mengontrol Manajemen Kualitas Menggunakan Cobit 4.1 (Studi Kasus : PT Nikkatsu Electric Works)

open access: yesJuTISI (Jurnal Teknik Informatika dan Sistem Informasi), 2015
— Information technology has become an important part in the organization, particularly for profit-oriented business organizations. PT Nikkatsu Electric Work is one of the companies that require information technology governance. Information technology
Rauf Fauzan, Rani Latifah
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

A study on the impact of non-operational mechanisms on the effectiveness of public information technology governance

open access: yesRAUSP: Revista de Administração da Universidade de São Paulo
This study proposes an analysis of non-operational mechanisms that can impact the effectiveness of information technology governance in the Brazilian public administration.
Leonel Cerqueira Santos   +1 more
doaj   +1 more source

Emerging models of power among South African women business leaders

open access: yesSA Journal of Industrial Psychology, 2016
Orientation: This paper represents a broader study which explores how South African women business leaders construct power in their life and leadership narratives.
Lisa Kinnear, Karen Ortlepp
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

ANALYSIS OF THE MECHANISM OF ETHICAL GOVERNANCE OF SCIENCE AND TECHNOLOGY ON SCIENTIFIC AND TECHNOLOGICAL INNOVATION

open access: yesJournal of Social Sciences
The uncertainty of the rapid development of science and technology has led to ethical risks that have attracted attention from all parties. As an important guarantee for the effective development of scientific and technological innovation activities, the
YANG, Xiaofei, WANG, Zuojun, ZHANG, Zile
doaj   +1 more source

The financing and governance of new technologies [PDF]

open access: yes, 2004
This paper examines the financial sector preconditions for the successful development of high technology sectors. It argues that there is a close relation between types of activities undertaken in different countries and their institutional structures.
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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