Results 71 to 80 of about 8,629 (213)

Leading sustainably in the digital era: a pilot study of AI literacy as a leadership competency in Estonian small and medium-sized enterprises [PDF]

open access: yesProceedings of the Estonian Academy of Sciences
The rapid digitalisation of organisational management has brought artificial intelligence (AI) into core decision-making processes, shaping managerial and human resource functions.
Aive Pevkur, Jaanus Mugu
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Leveraging tensions of the triple transition for future-fit energy pathways: Interdisciplinary analysis and response strategies

open access: yesFrontiers in Sustainable Energy Policy
Energy transitions operate at the intersection of multiple policy priorities, such as green, digital, and just transitions. While the policy discourse treats those priorities as synergetic, the real-world transition processes may feature tensions among ...
Vitaliy Soloviy   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Factors that influence computer programming proficiency in higher education

open access: yesSouth African Computer Journal
The industrial world has witnessed an increased demand for computing based skills due to the advent of robotics, artificial intelligence, and analytics.
Lerushka Ranjeeth, Indira Padayachee
doaj   +1 more source

Information Technology Governance on Audit Technology Performance among Malaysian Public Sector Auditors

open access: yesSocial Sciences, 2018
The concept of Industry 4.0 has considerably altered the way organisations operate and has impacted every aspect of life. Furthermore, the fast-growing trend of information technology (IT) transformation in organisations and huge IT investment by ...
Farida Veerankutty   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Procurement challenges in the Zimbabwean public sector: A preliminary study

open access: yesJournal of Transport and Supply Chain Management, 2015
Background: State Procurement Board procedures and the public procurement process have been blamed for the lagging behind of government projects that impact on public service delivery in Zimbabwe.
Abel Dzuke, Micheline J.A. Naude
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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