Results 31 to 40 of about 720,141 (268)

Information Technology Innovation [PDF]

The Permanente Journal, 2008
“Innovation is what distinguishes between a leader and a follower” is a statement often attributed to Apple cofounder Steve Jobs. Nowhere is this saying truer than in the realm of information technology (IT), where the blistering pace of change can make even casual observers dizzy. Yet IT innovation can be a two-edged sword.
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Financial Development, Technological Innovation, and Environmental Degradation: Evidence from Lower-Middle-Income Countries in Asia

ECONOMICS
This study analyzes the causal relationship between financial development and technological innovation, considering their impact on environmental degradation. The data sample covers nineteen lower-middle-income countries in Asia over the period 2000-2021.
Bui Ngoc Toan, Nguyen My-Linh Thi, Nguyen Bao-Chau Xuan   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Future industrial innovation: era trends, system functions, and development paths of high-tech industrial parks in China

Journal of Asian Architecture and Building Engineering
Future industry is the key driver of the new technological revolution and industrial transformation, and it has implications for national strategic security and global competitiveness. It is also the future direction of industrial innovation in high-tech
Jinglei Wang, Jing Zhao
doaj   +1 more source

Leveraging digital infrastructure for sustainable grain production: evidence from China

Frontiers in Sustainable Food Systems
IntroductionAgriculture faces significant challenges in ensuring global food security while minimizing resource costs and environmental impacts. The development of digital infrastructure offers transformative potential for agricultural systems and aligns
Jiabin Han, Wenting Ge, Yixiu Chou
doaj   +1 more source

IMPLEMENTATION OF INFORMATION TECHNOLOGY IN FINANCIAL SYSTEM AT UNIVERSITY X

Keunis, 2023
The rapid development of technology requires organizations to keep up with innovation in order to achieve competitive advantages. University X is a university that is beginning to prepare for this wave of change by implementing a system in the financial ...
Intan Ilsa Alma Retta, Theresia Dwi Hastuti   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source