Results 101 to 110 of about 3,163,990 (308)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
On Neural-Net Based Variable Structure Multiple Model Method: Neural-Net Design [PDF]
Journal of Systemics, Cybernetics and Informatics, 2003 In order to track a maneuvering target, multiple model (MM) methods have been researched. Almost MM algorithms have been developed based on Markov process. However, Markov based MM method is difficult to design and application-dependent.
Daebum Choi, Monica Samal, Byungha Ahn
doaj
The effects of forest canopy shading and turbulence on boundary layer ozone
Nature Communications, 2017 Fully quantifying the influence of vegetation on atmospheric chemistry remains challenging. Here, the authors show that forest canopy shading and turbulence significantly modify air pollution throughout the atmospheric boundary layer, and must be taken ...
P. A. Makar +8 more
doaj +1 more source
Capabilities of technology utilization and technology integration : Impact of 3D technologies on product development process and performance [PDF]
Multi-functional technologies widely influence on organization and often require organizational technology integration capabilities to achieve the total effectiveness.
Aoshima, Yaichi +2 more
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Nano-Micro LettersHighlights A bottom-up, strain-induced self-assembly strategy transforms 2D thin-film stacks into 3D coaxial Swiss-roll microsystems. Monolithic integration of a lithographically patterned, chemically tunable polyimide nanomembrane serves as a ...
Aleksandr I. Egunov +12 more
doaj +1 more source
Technology issues for shuttle main engine - Stage integration [PDF]
Stage integration requirements for space shuttle main ...
Mc Anelly, W. B. +2 more
core +1 more source
AFTI/F-16 digital flight control system experience [PDF]
, 1984 The Advanced Flighter Technology Integration (AFTI) F-16 program is investigating the integration of emerging technologies into an advanced fighter aircraft.
Mackall, D. A.
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source