Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Appraising the integration of sustainable development into sectoral policies: The case of Turkish Science & Technology policies [PDF]
This paper presents the results of a study investigating how sustainable development can be integrated in Turkish science and technology policies.
Cédric Gossart, Erkan Erdil
core
The influence of customer integration, integrated information technology, and relationship commitment on performance: a mediating and moderating analysis in supply chain management context [PDF]
, 2017 Esta investigación amplía el creciente cuerpo de la literatura sobre la integración de la cadena de suministro. A partir de diferentes teorías, desarrollamos hipótesis que proponen relaciones positivas entre la tecnología de información integrada, la ...
Abousamra, Alaa +3 more
core
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Transaction Cost, Technology Transfer and Mode of Organization [PDF]
We develop a monopolistically competitive model for a closed economy without contract incompleteness. We show that if superior technology is not allowed to be transferred, integration would be the best mode of organization given that the transaction cost
Mandal, Biswajit, Marjit, Sugata
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
能源环境保护Fiber-reinforced polymers (FRPs), composed of reinforcing fibers and resin matrices, exhibit outstanding characteristics such as low density, high strength, corrosion resistance, and superior mechanical performance.
Long JIAO +7 more
doaj +1 more source
Communication Aspects of the Integration of Wireless IoT Devices with Distributed Ledger Technology [PDF]
, 2020 Pietro Danzi +6 more
openalex +1 more source
Integrating Technologies Into Teaching and Learning Mathematics at the Beginning of Secondary Education in Austria [PDF]
, 2021 Robert Weinhandl +5 more
openalex +1 more source