Results 71 to 80 of about 899,857 (269)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Secure Coprocessor Integration with Kerberos V5

, 2000
The nightmare of Trusted Third Party (t3P) based protocol users is compromise of the T3P. Because the compromised T3P can read and modify any user information, the entire user group becomes vulnerable to secret revelation and user impersonation. Kerberos,
Itoi, Naomaru
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Integration of III-V Components of 5G Transceiver in Embedding PCB-Based Technology

III-V technology provides improved the RF performances in term of output power compared with standard CMOS technology. However, their integration into a system is challenging due to their thin top level contact made out of gold. Because of that, standard
Murugesan, Kavin Senthil, Lim, Tekfouy, Kosmider, Stefan, Ostmann, Andreas   +3 more
core   +1 more source

Integration of IC technology with MEMS:silicon+ technology for the future

, 2007
As silicon microelectronics continues its remarkable evolution, the technology is simultaneously scaling to smaller geometries and diversifying into new device types and associated novel application areas.
Henderson, R., Bunting, Andrew, Desmulliez, Marc Phillipe Yves; id_orcid, A.F. Murray, Stevenson, J. T.M., Walton, Anthony, Li, Y., Renshaw, David, MacIntosh, Mike, Flynn, David; id_orcid, Bunting, A., Henderson, Robert, Terry, Jonathan, Parkes, William, R. Henderson, C. Dunare, Holland, W. S., Holland, W S, Underwood, I, Muir, K, I. Underwood, W.S. Holland, MacIntosh, M J, A.J. Walton, Flynn, David, Tang, Tong Boon, Smith, S., Dunare, Camelia, Holland, Wayne, Terry, J. G., Desmulliez, M., Gundlach, A M, Tang, T. B., Parkes, W, Murray, A F, A.M. Gundlach, Murray, A. F., Underwood, I., MacIntosh, M. J., Li, Yifan, H. Lin, Parkes, W., D. Flynn, Tang, T B, W. Parkes, T.B. Tang, Bunting, A, J.G. Terry, Murray, Alan, Stevenson, Tom, Muir, K., Y. Li, Smith, S, Underwood, Ian, Desmulliez, Marc, Renshaw, D., D. Renshaw, Lin, H., Gundlach, A. M., Dunare, C., M. Desmulliez, Dunare, C, M.J. Maclntosh, Henderson, R, Lin, H, A. Bunting, Walton, A. J., Flynn, D., Terry, J, Stevenson, J T M, Renshaw, D, Li, Y, K. Muir, J.T.M. Stevenson, Walton, A J, S. Smith   +75 more
core   +1 more source

Novel Cu-nanowire-based technology enabling fine pitch interconnects for 2.5D/3D Integration

, 2023
118123This paper deals with the Cu-nanowire-based bonding technology for the fine-pitch interconnects. This Nano-material based bonding is a viable alternative to current state of the art Cu-SiO2 (oxide-oxide) hybrid bonding which is basically applicable
Shehzad, Adil, Birlem, Olav, Quednau, Sebastian, Wolf, Jürgen, Bickel, Steffen, Yin, Ran, Panchenko, Iuliana, Mueller, Maik   +7 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source