Results 261 to 270 of about 1,281,035 (364)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Authentic Leadership and Job Embeddedness Among Clinical Nurses: Mediating Roles of Perceived Insider Status and Organisational Identification. [PDF]

Nurs Open
Duan J, Li J, Tan Y, Jiao R, Liu X.
europepmc   +1 more source

Karel Davids, The Rise and Decline of Dutch Technological Leadership. Technology, Economy and Culture in the Netherlands, 1350-1800

, 2010
Lissa Roberts
openalex   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Academic and Demographic Characteristics of Orthopaedic Journal Editors-in-Chief. [PDF]

JB JS Open Access
Guirguis PG, Youssef MP, Malin M, Naguib D, Krotz M, Zimecka A, Botros M, Brodell JD, McDowell S.   +8 more
europepmc   +1 more source

The Relationship Between Perceived Leadership Behaviors and Job Satisfaction of Middle Managers : A Case Study at Motorola Technology (M) Sdn.Bhd [PDF]

, 2004
Khadijah Nordin
openalex  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Correction: Nutritional life cycle assessment for healthy and sustainable food systems: evidence and policy insights from Africa and Asia. [PDF]

Front Nutr
McAuliffe GA, Ortenzi F, van der Pols JC, Nemecek T, Colston J, Beal T.   +5 more
europepmc   +1 more source

Business Leadership in E-Commerce in the USA: The Impact of Blockchain Technology [PDF]

Bessouyah Mouna, Yassine Mimouni
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source