Results 91 to 100 of about 5,517,695 (292)

Integrating Circulated Technology into the Library Collection Development Plan [PDF]

open access: yes, 2018
Academic libraries are increasingly focused on the acquisition and expansion of circulating technology collections. These collections are often governed by auxiliary library services such as Access Services or IT departments and not considered as part of
Ordinario, Neil
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Evolutionary patterns and development prospects for e-government: a Delphi-based approach to perceptions of the administrative agent

open access: yesJournal of Business Economics and Management, 2014
Information technology is an open door for governments to service citizens in a more timely, cost-efficient and effective manner. Even considering citizen resistance, cultural adversity or changes in the economic agents’ relationship, few would contest ...
Fernando A. F. Ferreira   +4 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Technology Adoption in Nonrenewable Resource Management [PDF]

open access: yes
Nonrenewable resource scarcity has been a traditional concern when designing optimal growth models. Technological change has played an important role in those models, since its presence is assumed to mitigate the depletion effect on extraction paths over
Ana Balcão Reis   +2 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Big techy. Dylematy regulacji i konkurencji w badaniach i rozwoju AI

open access: yesStudia i Materiały
Objective: The article aims to examine the market power relations in artificial intelligence (AI) research and development, particularly the impact of AI basic models on the market power of big techs and platformization in the digital economy, regulation
Włodzimierz Szpringer
doaj   +1 more source

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