Results 111 to 120 of about 3,406,708 (296)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Design and Operating Performance of Mechanical Draft Dry Cooling Tower Pre-cooled with Wet Medium
Zhongguo dianliIn order to solve the problem of insufficient output of mechanical draft dry cooling tower which can’t meet the cooling demand in summer, a mechanical draft dry cooling tower with wet medium pre-cooling inlet air system is designed in this paper.
Mingwei WANG +6 more
doaj +1 more source
Cryogenic transfer options for exploration missions [PDF]
The literature of in-space cryogenic transfer is reviewed in order to propose transportation concepts to support the Space Exploration Initiative (SEI). Forty-nine references are listed and key findings are synopsized.
Chato, David J.
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Africa (COVID-19) Vaccine Technology Transfer: Where Are We? [PDF]
Life (Basel), 2023 Oladipo EK +6 more
europepmc +1 more source
The determinants of technology transfer efficiency and the role of innovation policies: a survey [PDF]
The diversity found in the various Technology Transfer Offices (TTOs), besides being a consequence of the capacities and motives of the different stakeholders involved (public research organisations, industry, consulting firms and public authorities ...
Aurora A.C. Teixeira +1 more
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The academics and technology transfer
California Agriculture, 1985 California Agriculture - All ...
L Lewis
doaj
OAST space research and technology applications: Technology transfer successes [PDF]
The ultimate measure of success in the Space Research and Technology Program is the incorporation of a technology into an operational mission. Charts are presented that describe technology products which OAST has helped support that (1) have been used in
Reck, Gregory M.
core +1 more source