Results 241 to 250 of about 10,992,361 (296)

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Reply to Commentary to Skudlik et al. (2023): why a scoping review and why only Germany?

BMC Nursing
Stefanie Skudlik, Julian Hirt, Tobias Döringer, Regina Thalhammer, Katharina Lüftl, Martin Müller   +5 more
doaj   +1 more source

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Sustainable Technology Transfer

Proceedings of the 2006 international workshop on Software technology transfer in software engineering, 2006
In this position paper we address the issue of transferring a technology from research into an industrial organization by presenting a refined process for technology transfer. Based on over two decades of industrial experience, we identified the need for a dedicated technology engineering phase for that process.
Punter, T., Krikhaar, R.L., Bril, R.J.
openaire   +3 more sources

Technology Transfer at Motorola

IEEE Software, 1994
While developing a formal software-review process, a working group at Motorola devised a technology-transfer model that is built on process packages, each one targeted to a different user group. Their model allows for tailoring, makes training and consulting widely available, and relies on champions.
Victor R. Basili, Michael Daskalantonakis, Robert H. Yacobellis   +2 more
openaire   +1 more source

Technology Transfer and Learning

Technology Analysis & Strategic Management, 2002
Despite the fact that international technology transfer has been widely studied its management still encounters many difficulties. To fully understand the issues that are relevant to the process of transferring production technology, it is necessary to determine the important factors that influence this process.
Steenhuis, Harm-Jan, de Bruijn, Erik J.
openaire   +2 more sources

Systems in Technology Transfer

Proceedings of the Thirtieth Hawaii International Conference on System Sciences, 1996
Contemporary technology transfer (TT) focuses on the application of knowledge. Technology is essentially information. Transfer is the movement of information/knowledge/technology via some type of channel (analogue or digital): person-to-person, group-to-group, organization- to-organization.TT centers on the communication of information that is intended
David V. Gibson, Suleiman K. Kassicieh
openaire   +2 more sources