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Technosphere® Insulin Technology

Diabetes Technology & Therapeutics, 2007
The ideal prandial insulin would possess characteristics of the insulin response profile seen in healthy individuals without diabetes. Approximating the early-phase insulin response that is lost in diabetes is challenging for injected insulins, especially achieving rapid insulin absorption and a favorable duration of metabolic effect.
Peter C, Richardson, Anders H, Boss
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Technosphere® Insulin

BioDrugs, 2010
Given the important role of insulin in the treatment of diabetes mellitus and in light of common barriers to insulin use, new strategies for insulin delivery by routes other than intravenous and subcutaneous injection have been investigated since the discovery of insulin in the 1920s.
Joshua J, Neumiller, R Keith, Campbell
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Technosphere insulin: inhaled prandial insulin

Expert Opinion on Biological Therapy, 2015
Insulin therapy is a mainstay for treatment of diabetes mellitus; however, many barriers to insulin exist. Insulin human inhalation powder (technosphere insulin) is a new FDA-approved alternative to subcutaneous bolus insulin.This is an overview of technosphere insulin (TI).
Tracy L, Setji   +2 more
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Technosphere inhaled insulin (Afrezza)

Drugs of Today, 2014
Technosphere® insulin uses a unique carrier -fumaryl diketopiperazine (FDKP)- which adsorbs insulin to form microparticles to permit delivery to the alveoli by inhalation. Toxicity studies have been entirely negative. The pulmonary absorption of insulin is very rapid, and the disappearance time is shorter than for subcutaneously delivered rapid-acting ...
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Inhaled technosphere regular insulin powder

Journal of the American Academy of Physician Assistants, 2015
The lungs are an effective way to deliver insulin for patients with diabetes, but an initial inhaled insulin product was withdrawn from the market because of high cost and inconsistent dosing. This article describes a recently approved inhaled insulin that appears to control blood glucose as well as rapid-acting injectable insulin.
Zachary L, Anderson   +1 more
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Safety of Technosphere Inhaled Insulin

Current Drug Safety, 2017
Technoshere insulin (TI), Afrezza, is a form of short-acting human insulin taken by oral inhalation with meals.literature search (English, French, Spanish) of all human studies and pertinent animal and in-vitro studies related to technosphere insulin until September 2016 with special emphasis on its safety.Compared to subcutaneous insulin aspart, TI is
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A Review of Inhaled Technosphere Insulin

Annals of Pharmacotherapy, 2010
Objective: To review the pharmacology, pharmacokinetics, efficacy, safety, and clinical use of Technosphere insulin. Data Sources: A MEDLINE search (1966–March 2010) was conducted for English-language articles using the terms AFREZZA, AFRESA, Technosphere insulin, pulmonary insulin, and inhaled insulin.
Joshua J, Neumiller   +2 more
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GEOECOLOGICAL FOUNDATIONS OF TECHNOSPHERE SAFETY

Естественные и технические науки, 2023
В статье анализируются возможности использования результатов геоэкологических исследований для обеспечения техносферной безопасности. Выделены их основные направления. The article analyzes the possibilities of using the results of geoecological research to ...
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Towards a Semiotics of the Technosphere

SSRN Electronic Journal, 2018
In current debates about the Anthropocene, the notion of ‘technosphere’ has gained analytical traction. It is loosely defined as the conjunction of all technological systems embodied in artefacts that have been created by humans since the domestication of fire and the invention of the first tools.
Hartley, John, Herrmann-Pillath, Carsten
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The Technosphere, Now

2016
The technosphere is an emergent weft of our geo-systemic fabric. The Technosphere project team of the Haus der Kulturen der Welt (HKW) and the para-academic collective and publication group continent. have collaborated here on an unwinding of technospheric matters, ideas and experiences, that we hope you, dear reader, will trace out with us.
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