Results 21 to 30 of about 1,476,323 (279)

Tecnologia social: uma estratégia para o desenvolvimento [PDF]

, 2004
Esta publicação apresenta reflexões de diversos representantes de instituições governamentais, do terceiro setor, da sociedade civil e de universidades sobre o tema da Tecnologia ...
Antonio E. Lassance, Jr., Claiton José Mello, Eduardo José Siqueira Barbosa, Flávio Cruvinel Brandão, Henrique Tahan Novaes, Jacqueline Rutkowski, Jacques De Oliveira Pena, Juçara Santiago Pedreira, Ladislau Dowbor, Paul Singer, Renato Dagnino, Sidney Lianza, Silvio Caccia Bava, Sonia Maria Portella Kruppa   +13 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Finding efficient nonlinear functions by means of genetic programming [PDF]

, 2003
7th International Conference, KES 2003. Proceedings, Part I. Oxford, UK, September 3-5, 2003The design of highly nonlinear functions is relevant for a number of different applications, ranging from database hashing to message authentication.
Hernández, Julio C., Isasi, Pedro, Luque, Cristóbal   +2 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Molecular analysis of anterior endoderm during Xenopus development: a funtional and genomic approach [PDF]

, 2008
Tese de doutoramento em Biologia (Biologia do Desenvolvimento), apresentada à Universidade de Lisboa através da Faculdade de Ciências, 2008Fundação para a Ciência e Tecnologia (FCT), (SFHR/BD/10035 ...
Silva, Ana Cristina Guerra Matos Ferreira da, 1979-
core  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Stock assessment and management of multi-species fisheries:the case study of flatfish fisheries in the portuguese coast [PDF]

, 2009
Tese de doutoramento, Biologia (Biologia Marinha), 2009, Universidade de Lisboa, Faculdade de CiênciasResumo alargado em português disponível no documentoFundação para a Ciência e Tecnologia (FCT), SFRH/BD/19319/2004 and the European Union FEDER ...
Dos santos teixeira, Célia
core  

Analysis of a class of boundary value problems depending on left and right Caputo fractional derivatives [PDF]

, 2017
In this work we study boundary value problems associated to a nonlinear fractional ordinary differential equation involving left and right Caputo derivatives.
Antunes, Pedro R. S., Ferreira, Rui A. C.   +1 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source