Results 41 to 50 of about 3,630 (136)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Evaluating the effect of ageing on interference resolution with time-varying complex networks analysis

Frontiers in Human Neuroscience, 2015
In this study we used graph theory analysis to investigate age-related reorganization of functional networks during the active maintenance of information that is interrupted by external interference.
Pedro eAriza, Elena eSolesio-Jofre, Johann eMartinez-Huartos, Johann eMartinez-Huartos, Jose A. Pineda Pardo, Guiomar eNiso, Guiomar eNiso, Fernando eMaestú, Javier M. Buldú, Javier M. Buldú   +9 more
doaj   +1 more source

Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Adverse social conditions across the life course influence brain aging and dementia, yet their compounded impact on clinical phenotypes remains underexplored, particularly in Latin America, where social inequality and dementia burden are high.
Temitope Farombi, Tiago Azzi, Agustina Legaz, David Aguillón, José Alberto Avila‐Funes, Maria Isabel Behrens, Martín Bruno, Juan Felipe Cardona, Nilton Custodio, Carolina Delgado, Stefanie Pina‐Escudero, Maria del Pilar Garavito Galofre, Marcelo Maito, Nahuel Magrath‐Guimet, Justin B. Miller, Diana Matallana, Maira Okada de Oliveira, Guido Rocatti, Elisa de Paula França Resende, Andrea Slachevsky, Leonel Takada, Olivia Wen, Lina M. Zapata‐Restrepo, Brian Lawlor, Kristine Yaffe, Kun Hu, Bruce Miller, Katherine Possin, Jennifer S. Yokoyama, Sol Fittipaldi, Adolfo M. García, Hernan Hernandez Larzabal, Hernando Santamaria‐Garcia, Enzo Tagliazzuchi, Claudia Duran‐Aniotz, Agustin Ibanez, Joaquin Migeot   +36 more
wiley   +1 more source

Telefarmácia no cuidado às pessoas com diabetes: uma revisão integrativa

RECIIS
O objetivo foi conhecer e sintetizar a literatura científica sobre o uso da telefarmácia no cuidado às pessoas com diabetes. Trata-se de uma revisão integrativa a partir de buscas de artigos nas bases de dados Medline/PUBMed, Embase, Scopus, Web of ...
Lucas Pedro dos Santos, Brenda Leandro dos Santos, Giselly de Almeida dos Santos, Priscila Torres, Rinaldo Eduardo Machado de Oliveira   +4 more
doaj   +1 more source

Use of the infusion pump in intensive care: perspectives of the nursing team

Revista de Enfermagem da Universidade Federal de Santa Maria, 2020
Objetivo: analisar as percepções dos profissionais de enfermagem sobre o uso da Bomba de Infusão no seu cotidiano em Terapia Intensiva. Método: estudo descritivo-exploratório, de abordagem qualitativa, realizado com 15 profissionais de enfermagem da ...
Jessika Oliveira Cavalaro, Nadia Raquel Suzini Camillo, João Lucas Campos de Oliveira, Kelly Cristina Inoue, Andressa Martins Dias Ferreira, Laura Misue Matsuda   +5 more
doaj   +1 more source

Modulation of the Stress Granule Component Carhsp1 Mitigates Disease‐Associated Deficits in Spinocerebellar Ataxia Type 3 Mouse Models

Movement Disorders, Volume 41, Issue 6, Page 1516-1527, June 2026.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) neurogenerative disorder that results from CAG trinucleotide repeat expansions in the ATXN3 gene, leading to toxic protein aggregate formation and cellular pathway dysfunction.
Tiago Moreira‐Gomes, Adriana Marcelo, Ana Teresa Rajado, Rafael G. Costa, Ricardo Afonso‐Reis, Cristiana R. Madeira, Inês T. Afonso, David V.C. Brito, Adriana A. Vaz, Clévio Nóbrega   +9 more
wiley   +1 more source

Long‐Term Colorectal Cancer Incidence After Adenoma and Serrated Polyp Removal: Results From the Colonprev Trial

United European Gastroenterology Journal, Volume 14, Issue 5, June 2026.
ABSTRACT Background The risk of colorectal cancer (CRC) after serrated polyp resection remains unclear, and current surveillance recommendations rely on limited evidence. We evaluated CRC incidence in individuals with advanced serrated lesions (ASL) detected at baseline colonoscopy and compared risk according to the most advanced lesion identified ...
Joaquín Cubiella, Carme García‐Benito, Antoni Castells, Enrique Quintero, Luis Bujanda, Susana Castán‐Cameo, José Díaz‐Tasende, Ángel Lanas, Akiko Ono, Eladio Frías‐Arrocha, Cristina Hernández, Rodrigo Jover, Montserrat Andreu, Fernando Carballo, Juan Diego Morillas, Dolores Salas, Cristina Regueiro‐Expósito, Pedro Davila‐Piñón, Astrid Diez‐Martín, on behalf of the COLONPREV study investigators   +19 more
wiley   +1 more source

m-Health no controle do câncer de colo do útero: pré-requisitos para o desenvolvimento de um aplicativo para smartphones

RECIIS, 2017
Com o objetivo de fornecer informações sobre o câncer do colo do útero (CCU), usando canais de comunicação presentes nos smartphones, o estudo apresentado neste artigo caracterizou o padrão de uso desses canais e a preferência de recebimento de ...
Carolina Correia Bilotti, Larissa Dalpiaz Nepomuceno, Gabriela Marengone Altizani, Regiane da Silva Macuch, Tiago Franklin Rodrigues Lucena, Flavio Bortolozzi, Marcelo Picinin Bernuci   +6 more
doaj   +1 more source

Avaliação de tecnologias em hospitais de ensino: desafios atuais.

Tempus Actas de Saúde Coletiva, 2015
Objetivo: Analisar as características estruturais e processos de trabalho após dois anos da implementação de centros de avaliação da tecnologia em hospitais de ensino no Brasil.
Flávia Tavares Silva ELIAS, Luciana Simões C LEÃO, Eduardo Coura ASSIS   +2 more
doaj  

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, Volume 293, Issue 11, Page 3376-3398, June 2026.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source