Results 111 to 120 of about 10,097 (254)

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, Volume 117, Issue 4, Page 922-935, October 2026.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Evaluation of a prototype bioreactor based on slowly rotating drum. [PDF]

Cytotechnology
Ambrico A, Trupo M, Magarelli RA, Larocca V, Martino M, Modenese S, Vurro S.   +6 more
europepmc   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

La cooperazione tra gli stakeholder per la sostenibilità del nuovo paradigma farmaceutico in Italia. [PDF]

Glob Reg Health Technol Assess
Drago V, Di Brino E, Laurita R, Rumi F, Basile M, Pierini A, Ponzianelli A, Patarnello F, Ianna P, Drago F.   +9 more
europepmc   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

Artificial Intelligence and Virtual Screening to Identify Small Molecules Inhibiting Transglutaminase 2 for Investigation and Treatment of Breast Cancer

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Artificial Intelligence (AI)‐guided screening of nearly 10 million molecules hit the bull’s‐eye: G11, a new nonpeptidic inhibitor of transglutaminase 2. A stepwise path from in silico ranking to cell and biochemical assays identified G11 as the top hit. It induced apoptosis in transglutaminase 2 (TG2)‐rich breast cancer cells and inhibited purified TG2,
Carlo M. Bergamini, Niel M. Henriksen, Brianna Ryan, Taylor A. Prince, Anna Terrazzan, Pietro Ancona, Cristina Zuccato, Gianluca Aguiari, Valentina Rosta, Jeffrey W. Keillor, Alessandro Trentini, Nicoletta Bianchi   +11 more
wiley   +1 more source

Dual actionability of BMI1 activation and mitotic vulnerability defines adaptive Osimertinib resistance in EGFR-mutant NSCLC. [PDF]

Cell Death Dis
Armanetti P, Cabrera San Millan E, Di Nardo M, Mercatelli R, Cavallini C, Crucitta S, Del Re M, Chiodi A, Mosca E, Consiglio A, Losito N, Musio A, Menichetti L, Bramanti E, Ali A, Levantini E, Maroni G.   +16 more
europepmc   +1 more source

Photoelectrochemical Water Splitting With TiO2 Thin Films: Effects of Thickness, Porosity, and Illumination Configuration

ChemElectroChem, Volume 13, Issue 18, 19 September 2026.
An increase in surface area is not always an advantage for photoanodes; mesoporous TiO2 photoelectrodes present lower photoelectrocatalytic performance in oxygen evolution reaction due to a higher density of surface states that promote recombination, especially under frontal illumination.
Michael Zuarez‐Chamba, Lucas N. Mendioroz, Priscila Vensaus, Christian Robles, Sixto Giménez, Gastón Corthey, Galo J. A. A. Soler‐Illia   +6 more
wiley   +1 more source

Correction to: Assessing validity and reliability of the Benefit Finding Scale in Italian people with multiple sclerosis and their caregivers. [PDF]

Neurol Sci
Rosato R, Giordano A, Biolzi B, Chisari CG, Falautano M, Grobberio M, Niccolai C, Pietrolongo E, Quartuccio ME, Viterbo RG, Fave AD, Bassi M.   +11 more
europepmc   +1 more source

Gas Measurements Reveal Fractional Degassing and Water Interaction During a Flank Eruption of Pacaya Volcano (Guatemala)

Geophysical Research Letters, Volume 53, Issue 17, 16 September 2026.
Abstract SO2 flux and gas composition were measured during the 2021 flank eruption of Pacaya Volcano (Guatemala). The SO2 flux, measured with Tropomi, gradually rose from ∼2 to ∼30 kg/s over a 5 month period before the eruption. Field UV camera data showed that >95% of the SO2 was emitted from the summit crater.
Robin Campion, Ali Zare, Sébastien Valade, Denis Legrand, Gustavo Chigna, Yves Moussallam   +5 more
wiley   +1 more source