Results 101 to 110 of about 94,899 (297)

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

Squamous cell carcinoma of esophagus in a 15-year-old boy

open access: yesJournal of Indian Association of Pediatric Surgeons, 2010
A 15-year-old boy with well-differentiated squamous cell carcinoma of the lower esophagus is reported because of its rarity. The patient presented with dysphagia for 3 months and weight loss.
Hedawoo J, Nagdeve N, Sarve G
doaj  

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

open access: yesAdvanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang   +11 more
wiley   +1 more source

Understanding the Significance of the Teenage Mother in Contemporary Parenting Culture [PDF]

open access: yes
This paper attempts to understand the prominence given to teenage pregnancy in policy discussions since the late-1990s by contextualising it within a broader analysis of the contemporary \'culture of parenting\'.
Jan Macvarish
core  

To Assess the Impact of Oral Quality of Life (QoL) in Teenage Population with Habit History of Tobacco/Areca Nut/Gutka/Smoking Using OHIP-14 in Bhilai Region

open access: yesJournal of Indian Academy of Oral Medicine and Radiology
Aim: To assess the impact of Oral Quality of Life (QoL) in teenage population with habit history of tobacco/ areca nut/ gutka/ smoking using OHIP-14 in Bhilai region.
Swati Prasad   +3 more
doaj   +1 more source

By the nature of aggressive young players 13-16 years, specializing in various sports through the prism of this phenomenon among their peers-athletes [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2011
Shows the influence of training loads of different orientation on the development of aggressive athletes. The experiment involved 151 young athlete at the age of 13-15 years and 61 schoolgirls of the same age who do not engage in sports.
Khoroshykha Mikhail Fedorovich
doaj  

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

open access: yesAdvanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai   +7 more
wiley   +1 more source

[Concert Poster: Teenage Symphony]

open access: yes
Poster/flyer advertising a concert by Teenage Symphony with Hardin Sweaty and the Ready to Go, Swim Swim, and New Science Projects, at Club ...

core  

[News Clip: Miss Teenage America]

open access: yes, 1964
Video footage from the WBAP-TV television station in Fort Worth, Texas, to accompany a news story about Miss Teenage America resigning her title to marry the boy she ...
WBAP-TV (Television station : Fort Worth, Tex.)
core  

The question under consideration is the ways of determining the physical working capacity of juvenile sportsmen in the conditions of sport training (on the example of running test) on the basis of conducting single submaximal loading [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2010
The comparative analysis of physical capacity of young sportsmen is resulted 13-16 years. 30 teenagers took part in an inspection. Between two methods of determination of physical capacity of the trained and untrained teenagers by the specific loadings ...
Khoroshukha M.F.
doaj  

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