Results 121 to 130 of about 73,486 (308)

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Are there neighbourhood effects on teenage parenthood in the UK, and does it matter for policy? A review of theory and evidence [PDF]

This paper is a forerunner to an empirical study of neighbourhood effects on teenage parenthood using the British Cohort Study (BCS70). It reviews evidence for the existence of such effects within the quantitative 'neighbourhood effects' literature.
Dylan Kneale, Ruth Lupton
core  

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source

Gravidez na adolescência: um novo olhar

Psicologia: Ciência e Profissão
A gravidez na adolescência constitui tema de grande relevância na realidade social brasileira. O enfoque tradicional relaciona a gravidez como indesejada e decorrente da desinformação sexual das jovens.
Diana Dadoorian
doaj  

Men, masculinity and mayhem: Research into the perceptions and ideals of boys and young men regarding sexual health, relationships and sex

, 2006
This research was funded for a period of six months (October 2005 – March 2006) in light of the report entitled Mind the Gap: A sexual health needs assessment of young people aged 12 – 21 within Hull (Duncalf, 2005).
Duncalf, Zachari
core  

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Looked-After Children's Views of Sex and Relationships Education and Sexual Health Services. [PDF]

, 2007
This document reports on the findings from a project exploring teenage looked-after children's views of sex and relationships education and sexual health services.
Hashem, Ferhana, Billings, Jenny R., Macvarish, Jan   +2 more
core  

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Characteristics of Pregnancy and Birth Outcomes among Expectant Teenage Mothers: A Single Center of Retrospective Study of 10 Years Approach

Obgynia
Objective: This study aims to analyze the characteristics and birth outcomes of Indonesian adolescents who have experienced pregnancy. Methods: This study assessed hospital-based retrospective cross-sectional study of 112 deliveries of teenage pregnancy.
Hendri Tanjaya, Mutiara Riani, Budi Darmawan, Edihan Mardjuki   +3 more
doaj   +1 more source