Results 261 to 270 of about 506,083 (381)

Injuries and the risk of disability in teenagers and young adults [PDF]

, 1997
R. Appleton
openalex   +1 more source

Paracetamol and its metabolites in children and adults with spinal muscular atrophy – a population pharmacokinetic model

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of the study was to investigate whether differences in paracetamol pharmacokinetics (PK) between spinal muscular atrophy (SMA) patients and healthy controls (HC) could be attributed to specific clinical covariates. Methods Nonlinear mixed‐effects modelling (NONMEM 7.4) was used to develop a population PK model, explore covariates ...
Qiaolin Zhao, Marie Mostue Naume, Brenda C. M. de Winter, Thomas Krag, Sissel Sundell Haslund‐Krog, Karoline Lolk Revsbech, John Vissing, Helle Holst, Morten Hylander Møller, Tessa Munkeboe Hornsyld, Morten Dunø, Christina Engel Hoei‐Hansen, Alfred Peter Born, Per Bo Jensen, Mette Cathrine Ørngreen   +14 more
wiley   +1 more source

Risk Factors for Suicide among Adolescents in Bangka Belitung Island, Indonesia: a Qualitative Study Approach. [PDF]

Acta Med Philipp
Suherman, Keliat BA, Daulima NHC, Besral.   +3 more
europepmc   +1 more source

Analysis of 4616 clinical trial initial submissions received by the Medicines and Healthcare products Regulatory Agency between February 2019 and October 2023

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse clinical trial initial submissions received by the MHRA between February 2019 and October 2023. Methods Data on submissions were extracted from the clinical trials unit data bank. The primary end‐point was the type of clinical trial initial submissions.
Andrea Manfrin, Kingyin Lee, James Pound, Munir Pirmohamed, June Raine   +4 more
wiley   +1 more source

Drug–drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450

British Journal of Clinical Pharmacology, EarlyView.
Aims To assess the effect of a potent cytochrome P450 (CYP) 3A inhibitor and CYP inducer on the pharmacokinetics of ritlecitinib, a JAK3/TEC family kinase inhibitor, and assess the effect of ritlecitinib on the pharmacokinetics of CYP substrates (midazolam, efavirenz, tolbutamide, caffeine and oral contraceptives [ethinyl oestradiol and levonorgestrel])
Vivek S. Purohit, Yeamin Huh, Martin E. Dowty, Anna Plotka, Alexandre Lejeune, Hindu Kalluru, Brian Hee   +6 more
wiley   +1 more source

Health risk assessment via Monte Carlo simulation and sensitivity analysis for fluoride and nitrate content in bottled waters consumed in Kermanshah city, Iran. [PDF]

Sci Rep
Mianeh HY, Amiri L, Jafari A, Nourozi N.
europepmc   +1 more source

Severe hyperammonaemia in a previously healthy teenager [PDF]

, 2000
Peter Galloway, G.B. MacPhee, P Galéa, Polly Robinson   +3 more
openalex   +1 more source

Alterations of appetite‐regulating hormones in risperidone treated children and adolescents—a post hoc analysis of the SPACe study

British Journal of Clinical Pharmacology, EarlyView.
Weight gain and metabolic disruptions are common in children and adolescents treated with antipsychotics, but the underlying mechanisms are unclear, complicating prevention and treatment. This study examines the impact of risperidone on appetite‐regulating hormones (insulin, leptin and bioleptin) and their relationship to body weight changes over time.
Jiayi Liang, Brenda C. M. de Winter, Rebecca A. Hermans, Sanne M. Kloosterboer, Susanne Kuckuck, Izgi Bayraktar, Liesbeth F. C. van Rossum, Manon H. J. Hillegers, Sander A. A. van den Berg, Birgit C. P. Koch, Bram Dierckx   +10 more
wiley   +1 more source

Psychometric validation of the Bangla Digital Addiction Scale for Teenagers and its associated factors among adolescents: MeLiSA study. [PDF]

BJPsych Open
Al-Mamun F, Mamun MA, ALmerab MM, Islam J, Gozal D, Muhit M.   +5 more
europepmc   +1 more source

Pharmacokinetics and pharmacodynamics of empagliflozin in paediatric patients aged 10–17 years with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Aims To characterize the pharmacokinetics (PK) and PK/pharmacodynamics (PD) regarding glycosylated haemoglobin (HbA1c) lowering using the paediatric data from DINAMO and to assess differences compared with adults. Methods Population PK and PK/PD models previously developed for empagliflozin in adults and adolescents were re‐estimated in a Bayesian ...
Juliane Rascher, Shen Cheng, Curtis Johnston, Sebastian Härtter, Wojtyniak Jan‐Georg, Jan Marquard, Igor Tartakovsky, Lori M. B. Laffel   +7 more
wiley   +1 more source