Results 101 to 110 of about 654,292 (325)

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang   +9 more
wiley   +1 more source

The fragility of functional work systems in steel [PDF]

open access: yes, 1999
The I/N case offers insight into the interrelationship between work systems, living standards and performance. It demonstrates that a high road approach and functional work systems positively impact stakeholders’ lives, improve production efficiency and ...
Barnes, William, Konzelmann, Suzanne J.
core  

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

[Saadet Tek] [PDF]

open access: yes
Taha Toros Arşivi, Dosya No: 112-Leyla ...

core  

Analisis Penonjolan dan Kesinambungan Topik pada Teks Cerpen, Teks Prosedur, dan Teks Lingkungan

open access: yes, 2020
Berdasarkan hasil analisis di atas dapat disimpulkan bahwa topik itu merupakan sentral kedudukannya dalam wacana, topik ditonjolkan dan dipertahankan dan diacu oleh seluruh bagian wacana dan secara garis besar, wacana berperan penting dalam pembelajaran khususnya dalam hal meningkatkan literasi siswa, baik itu kemampuan membaca atau menulisnya.
openaire   +2 more sources

Nurr1 Orchestrates Claustrum Development and Functionality

open access: yesAdvanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan   +12 more
wiley   +1 more source

Flower Biology of Two Diospyros Species Neighborly Live at Csc Area: Do Pollen Viability and Tube Growth Rate Shire Endemic Distribution [PDF]

open access: yes, 2008
Aims of study were to compare flower structure, pollen viability and pollen tube growth rate of two Diospyros species neighborly live in Cibinong Science Centre (CSC) park, Diospyros blancoi and D.
Rachman, E. (Erlin)
core  

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen   +8 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

open access: yesBritish Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright   +8 more
wiley   +1 more source

Nevruz ve Günlerle İlgili Çağatayca Yazılmış Bir Metin Üzerine Değerlendirme

open access: yesUluslararası Uygur Araştırmaları Dergisi, 2019
Halk inanışları içerisinde günlerin önemli bir yeri vardır. Çok eski zamanlardan itibaren insanoğlu günlere özel anlamlar yüklemiş ve günleri karşılaştığı olumlu ya da olumsuz durumların sebebi olarak görmüş, yaşadığı iyi veya kötü şeyleri günlerle ...
Recep TEK
doaj  

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