Results 111 to 120 of about 108,041 (265)

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory, Gonzalo Villapalos Garcia, Dora Koller, Solomon Adams, Chad A. Bousman, Evangelia Eirini Tsermpini, Michelle Whirl‐Carrillo, Amy J. Turner, Volker M. Lauschke, Mohamed Nagy, Erin C. Boone, Teri E. Klein, Pablo Zubiaur, Andrea Gaedigk   +13 more
wiley   +1 more source

Patient‐Centric First‐in‐Human Dose Selection: An Ex Vivo Minimal Anticipated Biological Effect Level Approach for T‐Cell Engagers in Multiple Myeloma

Clinical Pharmacology &Therapeutics, EarlyView.
The minimal anticipated biological effect level (MABEL) approach to first‐in‐human (FIH) dose calculation can lead to long dose‐escalation periods before observing clinical activity. We used a novel ex vivo MABEL approach to calculate the FIH starting dose for forimtamig, a T‐cell bispecific antibody under investigation for the treatment of relapsed ...
Thomas E. Kraft, Estelle Marrer‐Berger, Sara Belli, Helene Haegel, Anneliese Schneider, Anna Maria Giusti, Michael Bscheider, Wolfgang Jacob, Martin Weisser, Laura Blanco, Nicolas Frances, Eva Rossmann, Guido Steiner, Aintzane Zabaleta Azpiroz, Bruno Paiva, Ludovic Martinet, Tanja Fauti   +16 more
wiley   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

TEK tyrosine kinase, endothelial (TEK; Tie2) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

Developmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr., Mia V. Call, Noah M. LeFever, Mya Aviles‐Carlos, Nikki M. Dolphin, Paolo E. Forni   +5 more
wiley   +1 more source

Test of Basic and Integrated Science Process Skills (T-BISPS): How do Form Four Students in Kelantan Fare?

Asian Journal of Assessment in Teaching and Learning, 2013
This study aims to gauge the acquisition level of science process skills (SPS) amongst Form 4 students, analysing the data by gender, school location, and two way interaction between gender and school location.
Mohd Al-Junaidi Mohamad, Eng Tek Eng Tek Ong   +1 more
doaj  

Inverse sky islands: lowland river valleys drive microbial divergence while high elevations select for convergence in massive mountain ecosystems

Ecography, EarlyView.
Mountain ecosystems are often interpreted through the lens of the ‘sky island' model, where high‐elevation habitats function as isolated archipelagos. However, this model's applicability to massive, topographically complex mountain ranges where highlands are continuous and lowlands are fragmented remains untested.
Yazhou Zhang, J. Aaron Hogan, Jianjun Wang, Wenguang Sun, Yaojun Ye, Xin Liu, Minshu Song, Hang Sun   +7 more
wiley   +1 more source

Developing a Suitable Anion Exchange Layer Structure for Pure–Water Fed Bipolar Membrane CO2 Electrolysis

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A porous anion exchange layer (AEL) is implemented in a forward‐biased bipolar membrane CO2 electrolyzer to suppress carbonate crossover, support CO2 regeneration and maintain cathode alkalinity. Two fabrication strategies are compared—deposition on a silver gas diffusion electrode (GDE) or on the CEM—showing that a porous AEL‐coated GDE provides the ...
Henning Lorenz, Nico Roubicek, Simon Thiele, Chuyen van Pham   +3 more
wiley   +1 more source

Laser‐Textured Field‐Engineered Interface for Robust Dry‐Processed Cathodes in Lithium‐Ion Batteries

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Laser‐patterned dry electrodes applied to current collectors could serve as a promising alternative to the limitations of conventional dry electrodes. Laser technology provides a fast and simple method to enhance the surface roughness of current collectors, improving the adhesion at the electrode–current collector interface.
Chaerin Jung, Jinyeong Choi, Minsu Kim, Chaerim Kim, Minbong Park, Byungjoon Lee, Jae Ho Kim, Jin Hong Lee, Minjoon Park   +8 more
wiley   +1 more source

Uluslararası İletişimde Bir Sorun Olarak Haber ve Çözüm Önerileri

Selçuk İletişim, 2013
Bilgi Çağı olarak adlandırılan günümüzde toplumlar bilgiye her zamankinden fazla gereksinim duymaktadır. Bilgi artık, tek güç ve belirleyici olmuştur. Kitle iletişim araçları da toplumun tek haber ve bilgi kaynağı haline gelmiştir.
A.yalçın Kaya
doaj