Results 41 to 50 of about 219,281 (309)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Angiopoietin receptor TEK interacts with CYP1B1 in primary congenital glaucoma

Human Genetics, 2017
Primary congenital glaucoma (PCG) is a severe autosomal recessive ocular disorder associated with considerable clinical and genetic heterogeneity. Recently, rare heterozygous alleles in the angiopoietin receptor-encoding gene TEK were implicated in PCG ...
M. Kabra, Wei Zhang, S. Rathi, A. Mandal, S. Senthil, Goutham Pyatla, Muralidhar Ramappa, Seema Banerjee, Konegari Shekhar, Srinivas Marmamula, A. L. Mettla, I. Kaur, R. Khanna, H. Khanna, S. Chakrabarti   +14 more
semanticscholar   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

New Spirit and New Hero: How Hungarian Startups Redefine the Ideas of Local Capitalism

Studia Universitatis Babes-Bolyai Sociologia, 2016
The present paper investigates how the Bridge Budapest, a CSR organization founded by leading Hungarian IT startups, attempts to shape the values of Hungarian society towards capitalism in general, and towards entrepreneurship in particular.
Szabó Natasa
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Anadolu Türk Halk Hekimliğinde Toprak

Selçuk Üniversitesi Edebiyat Fakültesi Dergisi, 2018
Anasır-ı erbaa olarak nitelendirilen dört unsurdan biri olan toprak, tarihi süreç içerisinde pek çok kültür ve dinde kutsal kabul edilmiştir. Varoluşun esasını oluşturduğuna inanılan hava, su, ateş ile birlikte toprak, Türkler tarafından da “ıduk yer-sub”
Recep Tek
doaj   +1 more source

Teks Deksripsi

, 2023
Teks deskripsi adalah jenis tulisan yang berfokus pada penjelasan rinci tentang karakteristik fisik, visual, atau sensori dari suatu subjek. Tujuan utama dari teks deskripsi adalah untuk membantu pembaca membentuk gambaran yang jelas dan hidup dalam pikiran mereka tentang objek yang ...
openaire   +1 more source

The Influence of Hyperlipidemia on Endothelial Function of FPN1 Tek-Cre Mice and the Intervention Effect of Tetramethylpyrazine

Cellular Physiology and Biochemistry, 2018
Background/Aims: Systemic iron homeostasis is strictly governed in mammals; however, disordered iron metabolism (such as excess iron burden) is recognized as a risk factor for various types of diseases including AS (Atherosclerosis).
Ming-yue Sun, Miao Zhang, Shui-Ling Chen, Shuping Zhang, Chun-yu Guo, Jing-shang Wang, Xin Liu, Yang Miao, H. Yin   +8 more
semanticscholar   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

INOVASI PEMBELAJARAN TEKS MELALUI TEKS PUISI

LANGUAGE : Jurnal Inovasi Pendidikan Bahasa dan Sastra
ABSTRACT Literature learning is a crucial element in character development, aesthetic sensitivity, and the enhancement of critical thinking skills. However, literature learning often tends to be monotonous. The presence of poetry texts is recommended as an innovation in literature teaching.
Tri Wahyuni, Darni Darni, Resdianto Permata Raharjo   +2 more
openaire   +1 more source