Results 61 to 70 of about 108,041 (265)

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Teks op teks op teks: intertekstualiteit in Ingrid Winterbach se Niggie

Literator, 2006
Text on text on text: intertextuality in Ingrid Winterbach’s Niggie This article focuses on the creative adaptation of Anglo-Boer War material in Ingrid Winterbach’s (formerly Lettie Viljoen) “Niggie” (“Cousin”) (2002) with specific reference to the historiographical-metafictional element and intertextual game with texts written during or shortly after
M. Botha, H. van Vuuren
openaire   +1 more source

Mediasten Hastalıklarında Tek İnsizyon Video Yardımlı Torakoskopik Cerrahi: Tek Merkezli Bir Çalışma

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 2019
Giriş: Videoyardımlı torakoskopik cerrahi (VATS), hasta akıbetinde kanıtlanmışiyileşmeler sağladığından sonon yılda tüm dünyada yaygın bir popülerlikkazanmıştır.
Gökhan Ergene, H.semih Halezeroğlu, Erdal Okur, Mehmet Polat Demirhas, Fatma Tokat   +4 more
doaj   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Kontekstualisasi Filologi dalam Teks-teks Islam Nusantara

IBDA` : Jurnal Kajian Islam dan Budaya, 2016
This paper aims to explore the concepts, methods and significance of philology Islam Nusantara and contextualization in manuscripts from Indonesia. It departs from the problems that the Islamic manuscripts archipelago that has not been widely studied, whereas in it save the value, thought and culture of the past scholars Nusantara which would clarify ...
openaire   +4 more sources

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Examining the landscape transformation and temperature dynamics in Pakistan

Scientific Reports
This study aims to examine the landscape transformation and temperature dynamics using multiple spectral indices. The processes of temporal fluctuations in the land surface temperature is strongly related to the morphological features of the area in ...
Awais Ali, Bilal Hussain, Riaz Ul Hissan, Khalid M. Al Aiban, Magdalena Radulescu, Cosimo Magazzino   +5 more
doaj   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Large field of view, fast and low dose multimodal phase-contrast imaging at high x-ray energy

Scientific Reports, 2017
X-ray phase contrast imaging (XPCI) is an innovative imaging technique which extends the contrast capabilities of ‘conventional’ absorption based x-ray systems.
Alberto Astolfo, Marco Endrizzi, Fabio A. Vittoria, Paul C. Diemoz, Benjamin Price, Ian Haig, Alessandro Olivo   +6 more
doaj   +1 more source